Symptomatic psychosis risk and physiological fluctuation in functional MRI data

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Saarinen , A , Lieslehto , J , Kiviniemi , V , Häkli , J , Tuovinen , T , Hintsanen , M & Veijola , J 2020 , ' Symptomatic psychosis risk and physiological fluctuation in functional MRI data ' , Schizophrenia Research , vol. 216 , pp. 339-346 . https://doi.org/10.1016/j.schres.2019.11.029

Title: Symptomatic psychosis risk and physiological fluctuation in functional MRI data
Author: Saarinen, Aino; Lieslehto, Johannes; Kiviniemi, Vesa; Häkli, Jani; Tuovinen, Timo; Hintsanen, Mirka; Veijola, Juha
Other contributor: University of Helsinki, Medicum
University of Helsinki, University of Oulu

Date: 2020-02
Language: eng
Number of pages: 8
Belongs to series: Schizophrenia Research
ISSN: 0920-9964
DOI: https://doi.org/10.1016/j.schres.2019.11.029
URI: http://hdl.handle.net/10138/322332
Abstract: Background Physiological brain pulsations have been shown to play a critical role in maintaining interstitial homeostasis in the glymphatic brain clearance mechanism. We investigated whether psychotic symptomatology is related to the physiological variation of the human brain using fMRI. Methods The participants (N = 277) were from the Northern Finland Birth Cohort 1986. Psychotic symptoms were evaluated with the Positive Symptoms Scale of the Structured Interview for Prodromal Syndromes (SIPS). We used the coefficient of variation of BOLD signal (CVBOLD) as a proxy for physiological brain pulsatility. The CVBOLD-analyses were controlled for motion, age, sex, and educational level. The results were also compared with fMRI and voxel-based morphometry (VBM) meta-analyses of schizophrenia patients (data from the Brainmap database). Results At the global level, participants with psychotic-like symptoms had higher CVBOLD in cerebrospinal fluid (CSF) and white matter (WM), when compared to participants with no psychotic symptoms. Voxel-wise analyses revealed that CVBOLD was increased, especially in periventricular white matter, basal ganglia, cerebellum and parts of the cortical structures. Those brain regions, which included alterations of physiological fluctuation in symptomatic psychosis risk, overlapped
Subject: BRAIN ACTIVITY
CEREBROSPINAL-FLUID
HEART-RATE-VARIABILITY
METAANALYSIS
NOISE
OULU BRAIN
Physiological fluctuation
Prodromal symptoms
Psychosis, SPIS
RELIABILITY
SCHIZOPHRENIA
WHITE-MATTER
YOUNG-PEOPLE
fMRI
515 Psychology
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