Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations
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Toresson , L , Steiner , J M , Spodsberg , E , Olmedal , G , Suchodolski , J S , Lidbury , J A & Spillmann , T 2019 , ' Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations ' , Veterinary Journal , vol. 243 , pp. 8-14 . https://doi.org/10.1016/j.tvjl.2018.11.004
| Title: | Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations |
| Author: | Toresson, L.; Steiner, J. M.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Lidbury, J. A.; Spillmann, T. |
| Contributor organization: | Equine and Small Animal Medicine Faculty of Veterinary Medicine Thomas Spillmann / Principal Investigator Helsinki One Health (HOH) |
| Date: | 2019-01 |
| Language: | eng |
| Number of pages: | 7 |
| Belongs to series: | Veterinary Journal |
| ISSN: | 1090-0233 |
| DOI: | https://doi.org/10.1016/j.tvjl.2018.11.004 |
| URI: | http://hdl.handle.net/10138/322437 |
| Abstract: | The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285 ng/L (reference interval (RI): 244-959 ng/L) were treated with PO (0.25-1.0 mg daily) or PE cobalamin (0.25-1.2 mg/injection) using a block-randomized schedule. Serum MMA and HCY concentrations were analysed at day 0, 28 and 90 after start of supplementation. There was no significant difference between the PO and PE group regarding serum MMA or HCY concentrations at any time point. Median (range, P comparing baseline and 28 days, P comparing 28 days and 90 days) serum MMA concentrations (nmol/L; RI 415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at baseline, respectively, 705 (386-1465, P |
| Subject: |
Chronic enteropathy
Dog Inflammatory bowel disease Oral supplementation Vitamin B12 FAILURE-TO-THRIVE SERUM COBALAMIN BORDER COLLIES DEFICIENCY HYPERHOMOCYSTEINEMIA MALABSORPTION VITAMIN-B-12 ASSOCIATION DIAGNOSIS SECONDARY 413 Veterinary science |
| Peer reviewed: | Yes |
| Rights: | cc_by_nc_nd |
| Usage restriction: | openAccess |
| Self-archived version: | acceptedVersion |
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