Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations

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Toresson , L , Steiner , J M , Spodsberg , E , Olmedal , G , Suchodolski , J S , Lidbury , J A & Spillmann , T 2019 , ' Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations ' , Veterinary Journal , vol. 243 , pp. 8-14 . https://doi.org/10.1016/j.tvjl.2018.11.004

Title: Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations
Author: Toresson, L.; Steiner, J. M.; Spodsberg, E.; Olmedal, G.; Suchodolski, J. S.; Lidbury, J. A.; Spillmann, T.
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Thomas Spillmann / Principal Investigator
Date: 2019-01
Language: eng
Number of pages: 7
Belongs to series: Veterinary Journal
ISSN: 1090-0233
URI: http://hdl.handle.net/10138/322437
Abstract: The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285 ng/L (reference interval (RI): 244-959 ng/L) were treated with PO (0.25-1.0 mg daily) or PE cobalamin (0.25-1.2 mg/injection) using a block-randomized schedule. Serum MMA and HCY concentrations were analysed at day 0, 28 and 90 after start of supplementation. There was no significant difference between the PO and PE group regarding serum MMA or HCY concentrations at any time point. Median (range, P comparing baseline and 28 days, P comparing 28 days and 90 days) serum MMA concentrations (nmol/L; RI 415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at baseline, respectively, 705 (386-1465, P
Subject: Chronic enteropathy
Dog
Inflammatory bowel disease
Oral supplementation
Vitamin B12
FAILURE-TO-THRIVE
SERUM COBALAMIN
BORDER COLLIES
DEFICIENCY
HYPERHOMOCYSTEINEMIA
MALABSORPTION
VITAMIN-B-12
ASSOCIATION
DIAGNOSIS
SECONDARY
413 Veterinary science
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