Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study

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Tischmann , L , Drummen , M , Gatta-Cherifi , B , Raben , A , Fogelholm , M , Hartmann , B , Holst , J J , Matias , I , Cota , D , Mensink , R P , Joris , P J , Westerterp-Plantenga , M S & Adam , T C 2019 , ' Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study ' , Nutrients , vol. 11 , no. 10 , 2269 . https://doi.org/10.3390/nu11102269

Title: Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study
Author: Tischmann, Lea; Drummen, Mathijs; Gatta-Cherifi, Blandine; Raben, Anne; Fogelholm, Mikael; Hartmann, Bolette; Holst, Jens J.; Matias, Isabelle; Cota, Daniela; Mensink, Ronald P.; Joris, Peter J.; Westerterp-Plantenga, Margriet S.; Adam, Tanja C.
Contributor: University of Helsinki, Department of Food and Nutrition
Date: 2019-10
Language: eng
Number of pages: 16
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/322615
Abstract: Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 +/- 5.9 years; body mass index (BMI) 28.9 +/- 3.9 kg/m(2)) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p <0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p <0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p <0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.
Subject: Protein
endocannabinoids
hunger
satiety
gut peptides
weight maintenance
obesity
GLUCAGON-LIKE PEPTIDE-1
HIGH-PROTEIN DIET
BODY-WEIGHT
ENERGY-EXPENDITURE
SUBSTRATE METABOLISM
RESPIRATION CHAMBER
SEDENTARY BEHAVIOR
SYSTEM
GHRELIN
SATIETY
3143 Nutrition
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