The progress in corneal translational medicine

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Hancox , Z , Keshel , S H , Yousaf , S , Saelnasab , M , Shahbazi , M-A & Sefat , F 2020 , ' The progress in corneal translational medicine ' , Biomaterials Science , vol. 8 , no. 23 , pp. 6469-6504 . https://doi.org/10.1039/d0bm01209b

Title: The progress in corneal translational medicine
Author: Hancox, Zoe; Keshel, Saeed Heidari; Yousaf, Safiyya; Saelnasab, Morvarid; Shahbazi, Mohammad-Ali; Sefat, Farshid
Contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
Date: 2020-12-07
Language: eng
Number of pages: 36
Belongs to series: Biomaterials Science
ISSN: 2047-4830
URI: http://hdl.handle.net/10138/322669
Abstract: Cornea tissue is in high demand by tissue donation centres globally, and thus tissue engineering cornea, which is the main topic of corneal translational medicine, can serve as a limitless alternative to a donated human cornea tissue. Tissue engineering aims to produce solutions to the challenges associated with conventional cornea tissue, including transplantation and use of human amniotic membrane (HAM), which have issues with storage and immune rejection in patients. Accordingly, by carefully selecting biomaterials and fabrication methods to produce these therapeutic tissues, the demand for cornea tissue can be met, with an improved healing outcome for recipients with less associated harmful risks. In this review paper, we aim to present the recent advancements in the research and clinical applications of cornea tissue, applications including biomaterial selection, fabrication methods, scaffold structure, cellular response to these scaffolds, and future advancements of these techniques.
Subject: MESENCHYMAL STEM-CELLS
MUCOSAL EPITHELIAL TRANSPLANTATION
OCULAR SURFACE RECONSTRUCTION
HEPATOCYTE GROWTH-FACTOR
EX-VIVO EXPANSION
BONE-MARROW
EXTRACELLULAR-MATRIX
AMNIOTIC MEMBRANE
IN-VITRO
CHONDROITIN SULFATE
318 Medical biotechnology
317 Pharmacy
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