Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis

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http://hdl.handle.net/10138/322698

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Utz , B , Turpin , R , Lampe , J , Pouwels , J & Klefström , J 2020 , ' Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis ' , Scientific Reports , vol. 10 , no. 1 , 18733 . https://doi.org/10.1038/s41598-020-75411-z

Title: Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis
Author: Utz, Begüm; Turpin, Rita; Lampe, Johanna; Pouwels, Jeroen; Klefström, Juha
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
Date: 2020-10-30
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/322698
Abstract: Breast cancer is the most common form of cancer in women. Despite significant therapeutic advances in recent years, breast cancer also still causes the greatest number of cancer-related deaths in women, the vast majority of which (>90%) are caused by metastases. However, very few mouse mammary cancer models exist that faithfully recapitulate the multistep metastatic process in human patients. Here we assessed the suitability of a syngrafting protocol for a Myc-driven mammary tumor model (WAP-Myc) to study autochthonous metastasis. A moderate but robust spontaneous lung metastasis rate of around 25% was attained. In addition, increased T cell infiltration was observed in metastatic tumors compared to donor and syngrafted primary tumors. Thus, the WAP-Myc syngrafting protocol is a suitable tool to study the mechanisms of metastasis in MYC-driven breast cancer.
Subject: GROWTH-FACTOR-ALPHA
BREAST-CANCER
C-MYC
AMPLIFICATION
PROGRESSION
3111 Biomedicine
3122 Cancers
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