Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition

Show full item record



Permalink

http://hdl.handle.net/10138/322875

Citation

Hu , C , Hahn , L , Yang , M , Altmann , A , Stahlhut , P , Groll , J & Luxenhofer , R 2021 , ' Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition ' , Journal of Materials Science , vol. 56 , no. 1 , pp. 691-705 . https://doi.org/10.1007/s10853-020-05190-5

Title: Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition
Author: Hu, Chen; Hahn, Lukas; Yang, Mengshi; Altmann, Alexander; Stahlhut, Philipp; Groll, Jürgen; Luxenhofer, Robert
Contributor: University of Helsinki, Polymers
Date: 2021-01
Language: eng
Number of pages: 15
Belongs to series: Journal of Materials Science
ISSN: 0022-2461
URI: http://hdl.handle.net/10138/322875
Abstract: As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (similar to 1 s) and structure recovery (similar to 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay. Graphic abstract
Subject: TISSUE
POLY(2-OXAZOLINE)S
116 Chemical sciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Hu2021_Article_ ... rintabilityOfAThermo_1.pdf 1.870Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record