Drinking and mortality : long-term follow-up of drinking-discordant twin pairs

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dc.contributor.author Sipila, Pyry
dc.contributor.author Rose, Richard J.
dc.contributor.author Kaprio, Jaakko
dc.date.accessioned 2020-12-16T14:18:01Z
dc.date.available 2020-12-16T14:18:01Z
dc.date.issued 2016-02
dc.identifier.citation Sipila , P , Rose , R J & Kaprio , J 2016 , ' Drinking and mortality : long-term follow-up of drinking-discordant twin pairs ' , Addiction , vol. 111 , no. 2 , pp. 245-254 . https://doi.org/10.1111/add.13152
dc.identifier.other PURE: 60124587
dc.identifier.other PURE UUID: 033104ac-1dcf-4a82-b507-30896c6dae26
dc.identifier.other WOS: 000368940500008
dc.identifier.other Scopus: 84954234306
dc.identifier.other ORCID: /0000-0003-4886-8151/work/50565544
dc.identifier.uri http://hdl.handle.net/10138/323307
dc.description.abstract AimsTo determine if associations of alcohol consumption with all-cause mortality replicate in discordant monozygotic twin comparisons that control for familial and genetic confounds. DesignA 30-year prospective follow-up. SettingPopulation-based older Finnish twin cohort. ParticipantsSame-sex twins, aged 24-60years at the end of 1981, without overt comorbidities, completed questionnaires in 1975 and 1981 with response rates of 89 and 84%. A total of 15607 twins were available for mortality follow-up from the date of returned 1981 questionnaires to 31December 2011; 14787 twins with complete information were analysed. MeasurementsSelf-reported monthly alcohol consumption, heavy drinking occasions (HDO) and alcohol-induced blackouts. Adjustments for age, gender, marital and smoking status, physical activity, obesity, education and social class. FindingsAmong twins as individuals, high levels of monthly alcohol consumption (259g/month) associated with earlier mortality [hazard ratio (HR)=1.63, 95% confidence interval (CI)=1.47-1.81]. That association was replicated in comparisons of all informatively drinking-discordant twin pairs (HR=1.91, 95% CI=1.49-2.45) and within discordant monozygotic (MZ) twin pairs (HR=2.24, 95% CI=1.31-3.85), with comparable effect size. Smaller samples of MZ twins discordant for HDO and blackouts limited power; a significant association with mortality was found for multiple blackouts (HR=2.82, 95% CI=1.30-6.08), but not for HDO. ConclusionsThe associations of high levels of monthly alcohol consumption and alcohol-induced blackouts with increased all-cause mortality among Finnish twins cannot be explained by familial or genetic confounds; the explanation appears to be causal. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Addiction
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Alcohol drinking
dc.subject alcoholic intoxication
dc.subject binge drinking
dc.subject causality
dc.subject confounding factors
dc.subject follow-up studies
dc.subject mortality
dc.subject twins
dc.subject ALCOHOL-USE DISORDERS
dc.subject ALL-CAUSE MORTALITY
dc.subject CAUSAL INFERENCE
dc.subject RISK-FACTORS
dc.subject CONSUMPTION
dc.subject DISEASE
dc.subject METAANALYSIS
dc.subject BURDEN
dc.subject ENVIRONMENT
dc.subject PATTERN
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Drinking and mortality : long-term follow-up of drinking-discordant twin pairs en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization Jaakko Kaprio / Principal Investigator
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Genetic Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/add.13152
dc.relation.issn 0965-2140
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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