Multi-locus interactions and the build-up of reproductive isolation

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dc.contributor.author Satokangas, Ina
dc.contributor.author Martin, S. H.
dc.contributor.author Helanterä, H.
dc.contributor.author Saramaki, J.
dc.contributor.author Kulmuni, J.
dc.date.accessioned 2020-12-18T10:53:01Z
dc.date.available 2020-12-18T10:53:01Z
dc.date.issued 2020-08-31
dc.identifier.citation Satokangas , I , Martin , S H , Helanterä , H , Saramaki , J & Kulmuni , J 2020 , ' Multi-locus interactions and the build-up of reproductive isolation ' , Philosophical Transactions of the Royal Society. Biological Sciences , vol. 375 , 20190543 . https://doi.org/10.1098/rstb.2019.0543
dc.identifier.other PURE: 143467175
dc.identifier.other PURE UUID: a89a2946-22f0-4a47-8512-c9f78e3292b2
dc.identifier.other WOS: 000552662100012
dc.identifier.other ORCID: /0000-0002-8852-0793/work/79878865
dc.identifier.other ORCID: /0000-0002-2553-1487/work/80229929
dc.identifier.uri http://hdl.handle.net/10138/323392
dc.description.abstract All genes interact with other genes, and their additive effects and epistatic interactions affect an organism's phenotype and fitness. Recent theoretical and empirical work has advanced our understanding of the role of multi-locus interactions in speciation. However, relating different models to one another and to empirical observations is challenging. This review focuses on multi-locus interactions that lead to reproductive isolation (RI) through reduced hybrid fitness. We first review theoretical approaches and show how recent work incorporating a mechanistic understanding of multi-locus interactions recapitulates earlier models, but also makes novel predictions concerning the build-up of RI. These include high variance in the build-up rate of RI among taxa, the emergence of strong incompatibilities producing localized barriers to introgression, and an effect of population size on the build-up of RI. We then review recent experimental approaches to detect multi-locus interactions underlying RI using genomic data. We argue that future studies would benefit from overlapping methods like ancestry disequilibrium scans, genome scans of differentiation and analyses of hybrid gene expression. Finally, we highlight a need for further overlap between theoretical and empirical work, and approaches that predict what kind of patterns multi-locus interactions resulting in incompatibilities will leave in genome-wide polymorphism data. This article is part of the theme issue 'Towards the completion of speciation: the evolution of reproductive isolation beyond the first barriers'. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Philosophical Transactions of the Royal Society. Biological Sciences
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject multi-locus interactions
dc.subject networks
dc.subject speciation
dc.subject reproductive isolation
dc.subject epistasis
dc.subject incompatibility
dc.subject DOBZHANSKY-MULLER INCOMPATIBILITIES
dc.subject GENOME-WIDE DISSECTION
dc.subject GENE-EXPRESSION
dc.subject HYBRID INCOMPATIBILITY
dc.subject ADAPTIVE INTROGRESSION
dc.subject DIVERGENT SELECTION
dc.subject BIOPHYSICAL MODEL
dc.subject SMALL-WORLD
dc.subject EVOLUTION
dc.subject SPECIATION
dc.subject 1181 Ecology, evolutionary biology
dc.title Multi-locus interactions and the build-up of reproductive isolation en
dc.type Review Article
dc.contributor.organization Organismal and Evolutionary Biology Research Programme
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.contributor.organization Evolution, Sociality & Behaviour
dc.contributor.organization Tvärminne Zoological Station
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1098/rstb.2019.0543
dc.relation.issn 0962-8436
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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