A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs

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Nordgreen , J , Edwards , S A , Boyle , L A , Bolhuis , J E , Veit , C , Sayyari , A , Marin , D E , Dimitrov , I , Janczak , A M & Valros , A 2020 , ' A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs ' , Frontiers in Veterinary Science , vol. 7 , 646 . https://doi.org/10.3389/fvets.2020.00646

Title: A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs
Author: Nordgreen, Janicke; Edwards, Sandra A.; Boyle, Laura Ann; Bolhuis, J. Elizabeth; Veit, Christina; Sayyari, Amin; Marin, Daniela E.; Dimitrov, Ivan; Janczak, Andrew M.; Valros, Anna
Contributor: University of Helsinki, Production Animal Medicine
Date: 2020-10-02
Language: eng
Number of pages: 15
Belongs to series: Frontiers in Veterinary Science
ISSN: 2297-1769
URI: http://hdl.handle.net/10138/323397
Abstract: Sickness can change our mood for the worse, leaving us sad, lethargic, grumpy and less socially inclined. This mood change is part of a set of behavioral symptoms called sickness behavior and has features in common with core symptoms of depression. Therefore, the physiological changes induced by immune activation, for example following infection, are in the spotlight for explaining mechanisms behind mental health challenges such as depression. While humans may take a day off and isolate themselves until they feel better, farm animals housed in groups have only limited possibilities for social withdrawal. We suggest that immune activation could be a major factor influencing social interactions in pigs, with outbreaks of damaging behavior such as tail biting as a possible result. The hypothesis presented here is that the effects of several known risk factors for tail biting are mediated by pro-inflammatory cytokines, proteins produced by the immune system, and their effect on neurotransmitter systems. We describe the background for and implications of this hypothesis.
Subject: cytokines
pig
social behavior
tail biting
health-clinical
RESPIRATORY SYNDROME VIRUS
DEPRESSIVE-LIKE BEHAVIOR
NECROSIS-FACTOR-ALPHA
BLOOD-BRAIN-BARRIER
CHRONIC HEPATITIS-C
INDOLEAMINE 2,3-DIOXYGENASE
ENVIRONMENTAL ENRICHMENT
INTERFERON-ALPHA
RISK-FACTORS
ACUTE-PHASE
413 Veterinary science
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