Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line

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Kiiskinen , T , Korpi , E R & Aitta-aho , T 2019 , ' Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line ' , Behavioural Pharmacology , vol. 30 , no. 5 , pp. 405-411 . https://doi.org/10.1097/FBP.0000000000000449

Title: Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line
Author: Kiiskinen, Tuomo; Korpi, Esa R.; Aitta-aho, Teemu
Other contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Esa Risto Korpi / Principal Investigator
University of Helsinki, Department of Pharmacology





Date: 2019-08
Language: eng
Number of pages: 7
Belongs to series: Behavioural Pharmacology
ISSN: 0955-8810
DOI: https://doi.org/10.1097/FBP.0000000000000449
URI: http://hdl.handle.net/10138/323398
Abstract: Extinction and reinstatement of morphine-induced conditioned place preference were studied in glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor GluA1 subunit-deficient mice (global GluA1-KO mice). In line with previous findings, both acquisition and expression of conditioned place preference to morphine (20 mg/kg, subcutaneously) were fully functional in GluA1 KO mice compared with wild-type littermate controls (GluA1-WT), thus enabling the study of extinction. With a 10-session extinction paradigm, the GluA1 KO mice showed complete extinction similar to that of the GluA1-WT mice. Morphine-induced reinstatement (10 mg/kg, subcutaneously) was detected in both mouse lines. GluA1 KO mice moved more during all the phases of the experiment, including the place conditioning trials, extinction sessions, and place preference tests. The results suggest that the GluA1 subunit may be dispensable or prone to compensation at the neural circuitries delineating extinction and reinstatement. The GluA1 KO mice show altered long-term between-session habituation, which extends longer than previously anticipated.
Subject: 317 Pharmacy
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
conditioned place preference
extinction
glutamate
morphine
rat
reinstatement
COCAINE-INDUCED REINSTATEMENT
NUCLEUS-ACCUMBENS CORE
LONG-TERM POTENTIATION
AMPA RECEPTORS
SYNAPTIC PLASTICITY
GLUTAMATE RECEPTORS
DOPAMINE NEURONS
GLUR1 SUBUNIT
RELAPSE
SEEKING
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