Low-grade inflammation in first-episode psychosis is determined by increased waist circumference

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Keinänen , J , Suvisaari , J , Reinikainen , J , Kieseppä , T , Lindgren , M , Mantyla , T , Rikandi , E , Sundvall , J , Torniainen-Holm , M & Mantere , O 2018 , ' Low-grade inflammation in first-episode psychosis is determined by increased waist circumference ' , Psychiatry Research , vol. 270 , pp. 547-553 . https://doi.org/10.1016/j.psychres.2018.10.022

Title: Low-grade inflammation in first-episode psychosis is determined by increased waist circumference
Author: Keinänen, Jaakko; Suvisaari, Jaana; Reinikainen, Jaakko; Kieseppä, Tuula; Lindgren, Maija; Mantyla, Teemu; Rikandi, Eva; Sundvall, Jouko; Torniainen-Holm, Minna; Mantere, Outi
Contributor organization: Department of Psychiatry
University of Helsinki
Children's Hospital
HUS Children and Adolescents
HUS Psychiatry
Date: 2018-12
Language: eng
Number of pages: 7
Belongs to series: Psychiatry Research
ISSN: 0165-1781
DOI: https://doi.org/10.1016/j.psychres.2018.10.022
URI: http://hdl.handle.net/10138/323870
Abstract: Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) during the first treatment year. We recruited 95 FEP patients and 62 controls, and measured longitudinal changes in hs-CRP, weight, waist circumference, insulin resistance, and lipids. We used linear mixed models to analyze the longitudinal relationship between hs-CRP and clinical, anthropometric and metabolic measures. At baseline, patients with FEP had higher levels of insulin resistance, total and low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides. Baseline weight, waist circumference, hs-CRP, fasting glucose, and high-density lipoprotein cholesterol were similar between patients and controls. Marked increases in anthropometric measures and hs-CRP were observed in FEP during the 12-month follow-up. However, glucose and lipid parameters did not change significantly. In the mixed models, waist circumference and female sex were significant predictors of hs-CRP levels in FEP. Prevention of the early development of abdominal obesity in FEP is crucial, as abdominal obesity is accompanied by chronic low-grade inflammation, which increases further the cardiovascular risk in this vulnerable population.
Subject: Early psychosis
Chronic inflammation
C-reactive protein
Abdominal obesity
Weight gain
Cardiovascular risk
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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