The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood

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http://hdl.handle.net/10138/323906

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Westberg , A P , Kautiainen , H , Salonen , M K , Kajantie , E , von Bonsdorff , M & Eriksson , J G 2019 , ' The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood ' , Diabetes Research and Clinical Practice , vol. 158 , 107926 . https://doi.org/10.1016/j.diabres.2019.107926

Title: The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood
Author: Westberg, Anna P.; Kautiainen, Hannu; Salonen, Minna K.; Kajantie, Eero; von Bonsdorff, Mikaela; Eriksson, Johan G.
Contributor organization: Department of General Practice and Primary Health Care
University of Helsinki
HUS Helsinki and Uusimaa Hospital District
HUS Children and Adolescents
University Management
Lastentautien yksikkö
Children's Hospital
Research Programs Unit
Johan Eriksson / Principal Investigator
Clinicum
Date: 2019-12
Language: eng
Number of pages: 7
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
DOI: https://doi.org/10.1016/j.diabres.2019.107926
URI: http://hdl.handle.net/10138/323906
Abstract: Aims: We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods: This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied. Results: There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p <0.001) and mean homeostatic model assessment of insulin resistance (HOMA-IR) (p = 0.049). According to the subjects' own BMI, high maternal BMI was associated with lower 2-hour glucose concentrations only in non-obese men and with lower HOMA-IR only in obese men. Maternal BMI was not associated with glucose concentrations nor with HOMA-IR in women. In addition, maternal BMI was positively associated with a higher offspring lean body mass in men. Conclusions: High maternal BMI was associated with lower 2-hour plasma glucose concentration, especially in non-obese men. Offspring lean body mass may be a mediating factor for the association. (C) 2019 Elsevier B.V. All rights reserved.
Subject: Maternal obesity
Offspring health
BMI
Glucose metabolism
Insulin sensitivity
PANCREATIC BETA-CELL
BODY-MASS INDEX
INSULIN-RESISTANCE
MUSCLE MASS
OBESITY
HEALTH
RISK
GAIN
OVERWEIGHT
CHILDHOOD
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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