Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults : The NU-AGE Study

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van Soest , A P M , Hermes , G D A , Berendsen , A A M , van de Rest , O , Zoetendal , E G , Fuentes , S , Santoro , A , Franceschi , C , de Groot , L C P G M & de Vos , W M 2020 , ' Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults : The NU-AGE Study ' , Nutrients , vol. 12 , no. 11 , 3471 . https://doi.org/10.3390/nu12113471

Title: Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults : The NU-AGE Study
Author: van Soest, Annick P. M.; Hermes, Gerben D. A.; Berendsen, Agnes A. M.; van de Rest, Ondine; Zoetendal, Erwin G.; Fuentes, Susana; Santoro, Aurelia; Franceschi, Claudio; de Groot, Lisette C. P. G. M.; de Vos, Willem M.
Contributor: University of Helsinki, Willem Meindert Vos de / Principal Investigator
Date: 2020-11
Language: eng
Number of pages: 19
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/324091
Abstract: Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the 'New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe' (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro- to anti-inflammatory gradient associated with diets richer in animal- or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal- and plant-based foods were related to a pro- and anti-inflammatory microbial profile, while cognition was associated with neither.
Subject: gut microbiota
dietary intake
cognitive decline
elderly
healthy ageing
inflammation
GUT MICROBIOTA
MEDITERRANEAN DIET
BACTEROIDES
PROPIONATE
EXPRESSION
BUTYRATE
DISEASE
IMPACT
SCALE
3143 Nutrition
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