Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis

Show simple item record

dc.contributor.author Neumann, Alexander
dc.contributor.author Walton, Esther
dc.contributor.author Alemany, Silvia
dc.contributor.author Cecil, Charlotte
dc.contributor.author Gonzalez, Juan Ramon
dc.contributor.author Jima, Dereje D.
dc.contributor.author Lahti, Jari
dc.contributor.author Tuominen, Samuli T.
dc.contributor.author Barker, Edward D.
dc.contributor.author Binder, Elisabeth
dc.contributor.author Caramaschi, Doretta
dc.contributor.author Carracedo, Angel
dc.contributor.author Czamara, Darina
dc.contributor.author Evandt, Jorunn
dc.contributor.author Felix, Janine F.
dc.contributor.author Fuemmeler, Bernard F.
dc.contributor.author Gutzkow, Kristine B.
dc.contributor.author Hoyo, Cathrine
dc.contributor.author Julvez, Jordi
dc.contributor.author Kajantie, Eero
dc.contributor.author Laivuori, Hannele
dc.contributor.author Maguire, Rachel
dc.contributor.author Maitre, Lea
dc.contributor.author Murphy, Susan K.
dc.contributor.author Murcia, Mario
dc.contributor.author Villa, Pia M.
dc.contributor.author Sharp, Gemma
dc.contributor.author Sunyer, Jordi
dc.contributor.author Räikkönen, Katri
dc.contributor.author Bakermans-Kranenburg, Marian
dc.contributor.author van Ijzendoorn, Marinus
dc.contributor.author Guxens, Monica
dc.contributor.author Relton, Caroline L.
dc.contributor.author Tiemeier, Henning
dc.date.accessioned 2021-01-07T08:37:01Z
dc.date.available 2021-01-07T08:37:01Z
dc.date.issued 2020-11-12
dc.identifier.citation Neumann , A , Walton , E , Alemany , S , Cecil , C , Gonzalez , J R , Jima , D D , Lahti , J , Tuominen , S T , Barker , E D , Binder , E , Caramaschi , D , Carracedo , A , Czamara , D , Evandt , J , Felix , J F , Fuemmeler , B F , Gutzkow , K B , Hoyo , C , Julvez , J , Kajantie , E , Laivuori , H , Maguire , R , Maitre , L , Murphy , S K , Murcia , M , Villa , P M , Sharp , G , Sunyer , J , Räikkönen , K , Bakermans-Kranenburg , M , van Ijzendoorn , M , Guxens , M , Relton , C L & Tiemeier , H 2020 , ' Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis ' , Translational Psychiatry , vol. 10 , no. 1 , 398 . https://doi.org/10.1038/s41398-020-01058-z
dc.identifier.other PURE: 158767241
dc.identifier.other PURE UUID: 54cf54e2-529f-447b-820a-458624d18284
dc.identifier.other WOS: 000593958200001
dc.identifier.other ORCID: /0000-0002-4310-5297/work/86483092
dc.identifier.other ORCID: /0000-0003-3124-3470/work/86484988
dc.identifier.uri http://hdl.handle.net/10138/324196
dc.description.abstract Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA methylation sites associated with ADHD symptoms at two methylation assessment periods: birth and school age. We examined associations of both DNA methylation in cord blood with repeatedly assessed ADHD symptoms (age 4-15 years) in 2477 children from 5 cohorts and of DNA methylation at school age with concurrent ADHD symptoms (age 7-11 years) in 2374 children from 9 cohorts, with 3 cohorts participating at both timepoints. CpGs identified with nominal significance (p <0.05) in either of the EWAS were correlated between timepoints (rho = 0.30), suggesting overlap in associations; however, top signals were very different. At birth, we identified nine CpGs that predicted later ADHD symptoms (p <1 x 10(-7)), including ERC2 and CREB5. Peripheral blood DNA methylation at one of these CpGs (cg01271805 in the promoter region of ERC2, which regulates neurotransmitter release) was previously associated with brain methylation. Another (cg25520701) lies within the gene body of CREB5, which previously was associated with neurite outgrowth and an ADHD diagnosis. In contrast, at school age, no CpGs were associated with ADHD with p <1 x 10(-7). In conclusion, we found evidence in this study that DNA methylation at birth is associated with ADHD. Future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Translational Psychiatry
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
dc.subject COHORT PROFILE
dc.subject CHILD
dc.subject RISK
dc.subject GENE
dc.subject PERFORMANCE
dc.subject ACTIVATION
dc.subject PREGNANCY
dc.subject PACKAGE
dc.subject 515 Psychology
dc.subject 3124 Neurology and psychiatry
dc.title Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Children's Hospital
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Department of Medical and Clinical Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41398-020-01058-z
dc.relation.issn 2158-3188
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41398_020_01058_z.pdf 1.178Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record