Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis

Show simple item record Neumann, Alexander Walton, Esther Alemany, Silvia Cecil, Charlotte Gonzalez, Juan Ramon Jima, Dereje D. Lahti, Jari Tuominen, Samuli T. Barker, Edward D. Binder, Elisabeth Caramaschi, Doretta Carracedo, Angel Czamara, Darina Evandt, Jorunn Felix, Janine F. Fuemmeler, Bernard F. Gutzkow, Kristine B. Hoyo, Cathrine Julvez, Jordi Kajantie, Eero Laivuori, Hannele Maguire, Rachel Maitre, Lea Murphy, Susan K. Murcia, Mario Villa, Pia M. Sharp, Gemma Sunyer, Jordi Räikkönen, Katri Bakermans-Kranenburg, Marian van Ijzendoorn, Marinus Guxens, Monica Relton, Caroline L. Tiemeier, Henning 2021-01-07T08:37:01Z 2021-01-07T08:37:01Z 2020-11-12
dc.identifier.citation Neumann , A , Walton , E , Alemany , S , Cecil , C , Gonzalez , J R , Jima , D D , Lahti , J , Tuominen , S T , Barker , E D , Binder , E , Caramaschi , D , Carracedo , A , Czamara , D , Evandt , J , Felix , J F , Fuemmeler , B F , Gutzkow , K B , Hoyo , C , Julvez , J , Kajantie , E , Laivuori , H , Maguire , R , Maitre , L , Murphy , S K , Murcia , M , Villa , P M , Sharp , G , Sunyer , J , Räikkönen , K , Bakermans-Kranenburg , M , van Ijzendoorn , M , Guxens , M , Relton , C L & Tiemeier , H 2020 , ' Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis ' , Translational Psychiatry , vol. 10 , no. 1 , 398 .
dc.identifier.other PURE: 158767241
dc.identifier.other PURE UUID: 54cf54e2-529f-447b-820a-458624d18284
dc.identifier.other WOS: 000593958200001
dc.identifier.other ORCID: /0000-0002-4310-5297/work/86483092
dc.identifier.other ORCID: /0000-0003-3124-3470/work/86484988
dc.description.abstract Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA methylation sites associated with ADHD symptoms at two methylation assessment periods: birth and school age. We examined associations of both DNA methylation in cord blood with repeatedly assessed ADHD symptoms (age 4-15 years) in 2477 children from 5 cohorts and of DNA methylation at school age with concurrent ADHD symptoms (age 7-11 years) in 2374 children from 9 cohorts, with 3 cohorts participating at both timepoints. CpGs identified with nominal significance (p <0.05) in either of the EWAS were correlated between timepoints (rho = 0.30), suggesting overlap in associations; however, top signals were very different. At birth, we identified nine CpGs that predicted later ADHD symptoms (p <1 x 10(-7)), including ERC2 and CREB5. Peripheral blood DNA methylation at one of these CpGs (cg01271805 in the promoter region of ERC2, which regulates neurotransmitter release) was previously associated with brain methylation. Another (cg25520701) lies within the gene body of CREB5, which previously was associated with neurite outgrowth and an ADHD diagnosis. In contrast, at school age, no CpGs were associated with ADHD with p <1 x 10(-7). In conclusion, we found evidence in this study that DNA methylation at birth is associated with ADHD. Future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Translational Psychiatry
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject CHILD
dc.subject RISK
dc.subject GENE
dc.subject PERFORMANCE
dc.subject ACTIVATION
dc.subject PREGNANCY
dc.subject PACKAGE
dc.subject 515 Psychology
dc.subject 3124 Neurology and psychiatry
dc.title Association between DNA methylation and ADHD symptoms from birth to school age : a prospective meta-analysis en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Children's Hospital
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Department of Medical and Clinical Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2158-3188
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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