Narcolepsy type 1 : what have we learned from genetics?

Show full item record



Permalink

http://hdl.handle.net/10138/324358

Citation

Ollila , H M 2020 , ' Narcolepsy type 1 : what have we learned from genetics? ' , Sleep , vol. 43 , no. 11 , 099 . https://doi.org/10.1093/sleep/zsaa099

Title: Narcolepsy type 1 : what have we learned from genetics?
Author: Ollila, Hanna M.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2020-11
Language: eng
Number of pages: 7
Belongs to series: Sleep
ISSN: 0161-8105
URI: http://hdl.handle.net/10138/324358
Abstract: Type-1 narcolepsy is a severe neurological disorder with distinct characteristic of loss of hypocretin neurotransmitter. Genetic analysis in type-1 narcolepsy have revealed a unique signal pointing toward autoimmune, rather than psychiatric origin. While type-1 narcolepsy has been intensively studied, the other subtypes of hypersomnolence, narcolepsy, and hypersomnia are less thoroughly understood. This review summarizes the latest breakthroughs in the field in narcolepsy. The goal of this article is to help the reader to understand better the risk from genetic factors and their interplay with immune, genetic, and epidemiological aspects in narcolepsy.
Subject: narcolepsy
epidemiology
genetics
comorbidity
autoimmune
psychiatric
GENOME-WIDE ASSOCIATION
CONFER RISK
CATAPLEXY
SCHIZOPHRENIA
SUSCEPTIBILITY
PROTECTION
INFECTION
PROTEINS
DISEASE
STRESS
1184 Genetics, developmental biology, physiology
3112 Neurosciences
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
zsaa099.pdf 240.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record