Low-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes : a randomized parallel group trial

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Wasenius , N S , Isomaa , B A , Östman , B , Söderström , J , Forsen , B , Lahti , K , Hakaste , L , Eriksson , J G , Groop , L , Hansson , O & Tuomi , T 2020 , ' Low-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes : a randomized parallel group trial ' , BMJ Open Diabetes Research & Care , vol. 8 , no. 2 , 001377 . https://doi.org/10.1136/bmjdrc-2020-001377

Title: Low-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes : a randomized parallel group trial
Author: Wasenius, Niko S.; Isomaa, Bo A.; Östman, Bjarne; Söderström, Johan; Forsen, Björn; Lahti, Kaj; Hakaste, Liisa; Eriksson, Johan G.; Groop, Leif; Hansson, Ola; Tuomi, Tiinamaija
Contributor: University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Centre of Excellence in Complex Disease Genetics
Date: 2020
Language: eng
Number of pages: 11
Belongs to series: BMJ Open Diabetes Research & Care
ISSN: 2052-4897
URI: http://hdl.handle.net/10138/324363
Abstract: Introduction To investigate the effect of an exercise prescription and a 1-year supervised exercise intervention, and the modifying effect of the family history of type 2 diabetes (FH), on long-term cardiometabolic health. Research design and methods For this prospective randomized trial, we recruited non-diabetic participants with poor fitness (n=1072, 30-70 years). Participants were randomly assigned with stratification for FH either in the exercise prescription group (PG, n=144) or the supervised exercise group (EG, n=146) group and compared with a matched control group from the same population study (CON, n=782). The PG and EG received exercise prescriptions. In addition, the EG attended supervised exercise sessions two times a week for 60 min for 12 months. Cardiometabolic risk factors were measured at baseline, 1 year, 5 years, and 6 years. The CON group received no intervention and was measured at baseline and 6 years. Results The EG reduced their body weight, waist circumference, diastolic blood pressure, and low-density lipoprotein-cholesterol (LDL-C) but not physical fitness (p=0.074) or insulin or glucose regulation (p>0.1) compared with the PG at 1 year and 5 years (p Conclusions Low-cost physical activity programs have long-term beneficial effects on cardiometabolic health regardless of the FH of diabetes. Given the feasibility and low cost of these programs, they should be advocated to promote cardiometabolic health.
Subject: cardiorespiratory fitness
diabetes mellitus
type 2
exercise
metabolism
PHYSICAL-ACTIVITY
1ST-DEGREE RELATIVES
BODY-MASS
RISK
PREVENTION
RESISTANCE
PROGRAM
STRATIFICATION
METAANALYSIS
METABOLISM
3121 General medicine, internal medicine and other clinical medicine
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