Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes
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FinnDiane Study Grp , Pongrac Barlovic , D , Harjutsalo , V , Sandholm , N , Forsblom , C & Groop , P-H 2020 , ' Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes ' , Diabetologia , vol. 63 , no. 9 , pp. 1847-1856 . https://doi.org/10.1007/s00125-020-05201-9
| Title: | Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes |
| Author: | FinnDiane Study Grp; Pongrac Barlovic, Drazenka; Harjutsalo, Valma; Sandholm, Niina; Forsblom, Carol; Groop, Per-Henrik |
| Contributor organization: | Research Programs Unit University of Helsinki Nefrologian yksikkö HUS Abdominal Center Helsinki University Hospital Area CAMM - Research Program for Clinical and Molecular Metabolism Faculty of Medicine Medicum Clinicum Department of Medicine Per Henrik Groop / Principal Investigator |
| Date: | 2020-09 |
| Language: | eng |
| Number of pages: | 10 |
| Belongs to series: | Diabetologia |
| ISSN: | 0012-186X |
| DOI: | https://doi.org/10.1007/s00125-020-05201-9 |
| URI: | http://hdl.handle.net/10138/324375 |
| Abstract: | Aims/hypothesis Lipid abnormalities are associated with diabetic kidney disease and CHD, although their exact role has not yet been fully explained. Sphingomyelin, the predominant sphingolipid in humans, is crucial for intact glomerular and endothelial function. Therefore, the objective of our study was to investigate whether sphingomyelin impacts kidney disease and CHD progression in individuals with type 1 diabetes. Methods Individuals (n = 1087) from the Finnish Diabetic Nephropathy (FinnDiane) prospective cohort study with serum sphingomyelin measured using a proton NMR metabolomics platform were included. Kidney disease progression was defined as change in eGFR or albuminuria stratum. Data on incident end-stage renal disease (ESRD) and CHD were retrieved from national registries. HRs from Cox regression models and regression coefficients from the logistic or linear regression analyses were reported per 1 SD increase in sphingomyelin level. In addition, receiver operating curves were used to assess whether sphingomyelin improves eGFR decline prediction compared with albuminuria. Results During a median (IQR) 10.7 (6.4, 13.5) years of follow-up, sphingomyelin was independently associated with the fastest eGFR decline (lowest 25%; median [IQR] for eGFR change: |
| Subject: |
Albuminuria
Coronary artery disease Diabetic kidney disease Glomerular filtration rate Lipids NMR metabolomics Sphingomyelin KIDNEY-DISEASE INSULIN-RESISTANCE SPHINGOLIPID METABOLISM PLASMA CERAMIDES ARTERY-DISEASE ATHEROSCLEROSIS NEPHROPATHY INHIBITION COMPLICATIONS ASSOCIATION 3121 General medicine, internal medicine and other clinical medicine |
| Peer reviewed: | Yes |
| Rights: | unspecified |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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