Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

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Kim , C S , Ding , X , Allmeroth , K , Biggs , L C , Kolenc , O I , L'Hoest , N , Chacon-Martinez , C A , Edlich-Muth , C , Giavalisco , P , Quinn , K P , Denzel , M S , Eming , S A & Wickström , S A 2020 , ' Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle ' , Cell Metabolism , vol. 32 , no. 4 , pp. 629-+ . https://doi.org/10.1016/j.cmet.2020.08.011

Title: Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle
Author: Kim, Christine S.; Ding, Xiaolei; Allmeroth, Kira; Biggs, Leah C.; Kolenc, Olivia I.; L'Hoest, Nina; Chacon-Martinez, Carlos Andres; Edlich-Muth, Christian; Giavalisco, Patrick; Quinn, Kyle P.; Denzel, Martin S.; Eming, Sabine A.; Wickström, Sara A.
Contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Helsinki Institute of Life Science HiLIFE
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2020-10-06
Language: eng
Number of pages: 22
Belongs to series: Cell Metabolism
ISSN: 1550-4131
URI: http://hdl.handle.net/10138/324404
Abstract: Stem cells reside in specialized niches that are critical for their function. Upon activation, hair follicle stem cells (HFSCs) exit their niche to generate the outer root sheath (ORS), but a subset of ORS progeny returns to the niche to resume an SC state. Mechanisms of this fate reversibility are unclear. We show that the ability of ORS cells to return to the SC state requires suppression of a metabolic switch from glycolysis to oxidative phosphorylation and glutamine metabolism that occurs during early HFSC lineage progression. HFSC fate reversibility and glutamine metabolism are regulated by the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis within the niche. Deletion of mTORC2 results in a failure to re-establish the HFSC niche, defective hair follicle regeneration, and compromised long-term maintenance of HFSCs. These findings highlight the importance of spatiotemporal control of SC metabolic states in organ homeostasis.
Subject: MASS-SPECTROMETRY
SKIN
INHIBITION
GROWTH
HIF-1-ALPHA
TRANSPORT
CANCER
RICTOR
NICHE
CHAIN
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
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