Effectiveness and cost-effectiveness of personalised dietary advice aiming at increasing protein intake on physical functioning in community-dwelling older adults with lower habitual protein intake : rationale and design of the PROMISS randomised controlled trial

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Reinders , I , Wijnhoven , H A H , Jyväkorpi , S K , Suominen , M H , Niskanen , R , Bosmans , J E , Brouwer , I A , Fluitman , K S , Klein , M C A , Kuijper , L D , van der Lubbe , L M , Olthof , M R , Pitkälä , K H , Vijlbrief , R & Visser , M 2020 , ' Effectiveness and cost-effectiveness of personalised dietary advice aiming at increasing protein intake on physical functioning in community-dwelling older adults with lower habitual protein intake : rationale and design of the PROMISS randomised controlled trial ' , BMJ Open , vol. 10 , no. 11 , 040637 . https://doi.org/10.1136/bmjopen-2020-040637

Title: Effectiveness and cost-effectiveness of personalised dietary advice aiming at increasing protein intake on physical functioning in community-dwelling older adults with lower habitual protein intake : rationale and design of the PROMISS randomised controlled trial
Author: Reinders, Ilse; Wijnhoven, Hanneke A. H.; Jyväkorpi, Satu K.; Suominen, Merja H.; Niskanen, Riikka; Bosmans, Judith E.; Brouwer, Ingeborg A.; Fluitman, Kristien S.; Klein, Michel C. A.; Kuijper, Lothar D.; van der Lubbe, Laura M.; Olthof, Margreet R.; Pitkälä, Kaisu H.; Vijlbrief, Rachel; Visser, Marjolein
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Teachers' Academy
Date: 2020
Language: eng
Number of pages: 15
Belongs to series: BMJ Open
ISSN: 2044-6055
URI: http://hdl.handle.net/10138/324407
Abstract: Introduction Short-term metabolic and observational studies suggest that protein intake above the recommended dietary allowance of 0.83 g/kg body weight (BW)/day may support preservation of lean body mass and physical function in old age, but evidence from randomised controlled trials is inconclusive. Methods and analysis The PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS) trial examines the effect of personalised dietary advice aiming at increasing protein intake with or without advice regarding timing of protein intake to close proximity of usual physical activity, on change in physical functioning after 6 months among community-dwelling older adults (>= 65 years) with a habitual protein intake of Discussion The PROMISS trial will provide evidence whether increasing protein intake, and additionally optimising the timing of protein intake, has a positive effect on the course of physical functioning after 6 months among community-dwelling older adults with a habitual protein intake of Ethics and dissemination The study has been approved by the Ethics Committee of the Helsinki University Central Hospital, Finland (ID of the approval: HUS/1530/2018) and The Medical Ethical Committee of the Amsterdam UMC, location VUmc, Amsterdam, the Netherlands (ID of the approval: 2018.399). All participants provided written informed consent prior to being enrolled onto the study. Results will be submitted for publication in peer-reviewed journals and will be made available to stakeholders (ie, older adults, healthcare professionals and industry).
Subject: BIOELECTRICAL-IMPEDANCE ANALYSIS
LOWER-EXTREMITY FUNCTION
MUSCLE FAT INFILTRATION
RESISTANCE EXERCISE
SKELETAL-MUSCLE
MOBILITY LIMITATION
BODY-COMPOSITION
HEALTHY OLDER
DOUBLE-BLIND
WEIGHT-LOSS
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
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