Platelet-rich plasma versus corticosteroid injection for treatment of trigger finger : study protocol for a prospective randomized triple-blind placebo-controlled trial

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Aspinen , S , Nordback , P H , Anttila , T , Stjernberg-Salmela , S , Ryhänen , J & Kosola , J 2020 , ' Platelet-rich plasma versus corticosteroid injection for treatment of trigger finger : study protocol for a prospective randomized triple-blind placebo-controlled trial ' , Trials , vol. 21 , no. 1 , 984 . https://doi.org/10.1186/s13063-020-04907-w

Title: Platelet-rich plasma versus corticosteroid injection for treatment of trigger finger : study protocol for a prospective randomized triple-blind placebo-controlled trial
Author: Aspinen, Samuli; Nordback, Panu H.; Anttila, Turkka; Stjernberg-Salmela, Susanna; Ryhänen, Jorma; Kosola, Jussi
Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, Faculty of Medicine
University of Helsinki, Helsinki University Hospital Area
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
Date: 2020-12-27
Language: eng
Number of pages: 9
Belongs to series: Trials
ISSN: 1745-6215
URI: http://hdl.handle.net/10138/324415
Abstract: BackgroundTrigger finger is a common hand disorder that limits finger range of motion and causes pain and snapping of the affected finger. Trigger finger is caused by an imbalance of the tendon sheath and the flexor tendon. The initial treatment is generally a local corticosteroid injection around the first annular (A1) pulley. However, it is not unusual that surgical release of the A1 pulley is required. Moreover, adverse events after local corticosteroid injection or operative treatment may occur. Platelet-rich plasma (PRP) has been shown to be safe and to reduce symptoms in different tendon pathologies, such as DeQuervain's disease. However, the effects of PRP on trigger finger have not been studied. The aim of this single-center triple-blind randomized controlled trial is to study whether PRP is non-inferior to corticosteroid injection in treating trigger finger. The secondary outcome is to assess the safety and efficacy of PRP in comparison to placebo.MethodsThe trial is designed as a randomized, controlled, patient-, investigator-, and outcome assessor-blinded, single-center, three-armed 1:1:1 non-inferiority trial. The patients with clinical symptoms of trigger finger will be randomly assigned to treatment with PRP, corticosteroid, or normal saline injection. The primary outcome is Patient-Rated Wrist Evaluation and symptom resolution. Secondary outcomes include Quick-Disabilities of the Arm, Shoulder and Hand; pain; grip strength; finger active range of motion; and complications. Appropriate statistical methods will be applied.DiscussionWe present a novel RCT study design on the use of PRP for the treatment of trigger finger compared to corticosteroid and normal saline injection. The results of the trial will indicate if PRP is appropriate for the treatment of trigger finger.Trial registrationClinicalTrials.gov NCT04167098. Registered on November 18, 2019.
Subject: Clinical trial
Platelet-rich plasma
Trigger finger
Trigger thumb
Stenosing tenosynovitis
METAANALYSIS
TENDON
PAIN
3126 Surgery, anesthesiology, intensive care, radiology
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