Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer

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http://hdl.handle.net/10138/324427

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Heikkinen , I , Bello , I O , Wahab , A , Hagström , J , Haglund , C , Coletta , R D , Nieminen , P , Makitie , A A , Salo , T , Leivo , I & Almangush , A 2019 , ' Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer ' , American Journal of Surgical Pathology , vol. 43 , no. 10 , pp. 1392-1396 . https://doi.org/10.1097/PAS.0000000000001323

Title: Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer
Author: Heikkinen, Ilkka; Bello, Ibrahim O.; Wahab, Awais; Hagström, Jaana; Haglund, Caj; Coletta, Ricardo D.; Nieminen, Pentti; Makitie, Antti A.; Salo, Tuula; Leivo, Ilmo; Almangush, Alhadi
Contributor: University of Helsinki, Medicum
University of Helsinki, Department of Pathology
University of Helsinki, Department of Pathology
University of Helsinki, University Management
University of Helsinki, HUS Abdominal Center
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Head and Neck Center
Date: 2019-10
Language: eng
Number of pages: 5
Belongs to series: American Journal of Surgical Pathology
ISSN: 0147-5185
URI: http://hdl.handle.net/10138/324427
Abstract: Tumor-infiltrating lymphocytes (TILs) have shown a promising prognostic value in many epithelial cancers. We sought to assess the prognostic value of TILs in a multicenter cohort of early oral tongue squamous cell carcinoma (OTSCC). The percentage of TILs was assessed on the surgical resection slides stained with hematoxylin and eosin. The assessment of TILs was performed in the stromal compartment and in the intraepithelial compartment (at the invasive front and at the center of the tumor). We followed the method that was described recently by the International Immuno-Oncology Biomarker Working Group for the assessment of TILs. A total of 308 cases from the 5 Finnish university hospitals and from A.C. Camargo Cancer Center, Sao Paulo, Brazil, were included. We found a promising prognostic value for stromal TILs at the invasive front in the multivariable analysis with a hazard ratio of 2.61 (95% confidence interval [CI], 1.77-3.83; P
Subject: oral tongue squamous cell carcinoma (OTSCC)
tumor-infiltrating lymphocytes (TILs)
overall survival (OS)
disease-specific survival (DSS)
disease-free survival (DFS)
SQUAMOUS-CELL CARCINOMA
BIOMARKERS
313 Dentistry
3111 Biomedicine
3126 Surgery, anesthesiology, intensive care, radiology
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