Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

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ARIA Grp , the ARIA group , Bousquet , J , Cristol , J-P , Czarlewski , W , Haahtela , T , Erhola , M , Koskinen , S , Kuitunen , M , Strandberg , T , Toppila-Salmi , S & Von Hertzen , L 2020 , ' Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies ' , Clinical and Translational Allergy , vol. 10 , no. 1 , 58 . https://doi.org/10.1186/s13601-020-00362-7

Title: Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
Author: ARIA Grp; the ARIA group; Bousquet, Jean; Cristol, Jean-Paul; Czarlewski, Wienczyslawa; Haahtela, Tari; Erhola, Marina; Koskinen, Seppo; Kuitunen, Mikael; Strandberg, Timo; Toppila-Salmi, Sanna; Von Hertzen, Leena
Contributor: University of Helsinki, HUS Inflammation Center
University of Helsinki, Päijät-Häme Welfare Consortium
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Children's Hospital
University of Helsinki, Department of Medicine
University of Helsinki, Department of Pathology
University of Helsinki, Department of Dermatology, Allergology and Venereology
Date: 2020-12-03
Language: eng
Number of pages: 18
Belongs to series: Clinical and Translational Allergy
ISSN: 2045-7022
URI: http://hdl.handle.net/10138/324444
Abstract: There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Subject: COVID-19
Nrf2
Foods
Nutrients
Insulin resistance
Obesity
TRPA1
ENDOPLASMIC-RETICULUM STRESS
NF-KAPPA-B
ACUTE LUNG INJURY
RESPIRATORY SYNDROME CORONAVIRUS
MUSCLE-CELL PROLIFERATION
OXIDATIVE STRESS
INSULIN-RESISTANCE
SIGNALING PATHWAY
NRF2 ACTIVATORS
SULFORAPHANE PROTECTS
3121 General medicine, internal medicine and other clinical medicine
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