Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

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dc.contributor.author ARIA Grp
dc.contributor.author the ARIA group
dc.contributor.author Bousquet, Jean
dc.contributor.author Cristol, Jean-Paul
dc.contributor.author Czarlewski, Wienczyslawa
dc.contributor.author Haahtela, Tari
dc.contributor.author Erhola, Marina
dc.contributor.author Koskinen, Seppo
dc.contributor.author Kuitunen, Mikael
dc.contributor.author Strandberg, Timo
dc.contributor.author Toppila-Salmi, Sanna
dc.contributor.author Von Hertzen, Leena
dc.date.accessioned 2021-01-13T05:31:01Z
dc.date.available 2021-01-13T05:31:01Z
dc.date.issued 2020-12-03
dc.identifier.citation ARIA Grp , the ARIA group , Bousquet , J , Cristol , J-P , Czarlewski , W , Haahtela , T , Erhola , M , Koskinen , S , Kuitunen , M , Strandberg , T , Toppila-Salmi , S & Von Hertzen , L 2020 , ' Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies ' , Clinical and Translational Allergy , vol. 10 , no. 1 , 58 . https://doi.org/10.1186/s13601-020-00362-7
dc.identifier.other PURE: 158942455
dc.identifier.other PURE UUID: 95738e63-3530-4262-883b-c0bf9a82e371
dc.identifier.other WOS: 000595576200001
dc.identifier.other ORCID: /0000-0001-6299-925X/work/86938353
dc.identifier.other ORCID: /0000-0003-0890-6686/work/86938889
dc.identifier.uri http://hdl.handle.net/10138/324444
dc.description.abstract There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof Clinical and Translational Allergy
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject COVID-19
dc.subject Nrf2
dc.subject Foods
dc.subject Nutrients
dc.subject Insulin resistance
dc.subject Obesity
dc.subject TRPA1
dc.subject ENDOPLASMIC-RETICULUM STRESS
dc.subject NF-KAPPA-B
dc.subject ACUTE LUNG INJURY
dc.subject RESPIRATORY SYNDROME CORONAVIRUS
dc.subject MUSCLE-CELL PROLIFERATION
dc.subject OXIDATIVE STRESS
dc.subject INSULIN-RESISTANCE
dc.subject SIGNALING PATHWAY
dc.subject NRF2 ACTIVATORS
dc.subject SULFORAPHANE PROTECTS
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies en
dc.type Review Article
dc.contributor.organization HUS Inflammation Center
dc.contributor.organization Department of Dermatology, Allergology and Venereology
dc.contributor.organization University of Helsinki
dc.contributor.organization Päijät-Häme Welfare Consortium
dc.contributor.organization HYKS erva
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Children's Hospital
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Department of Medicine
dc.contributor.organization Timo Strandberg / Principal Investigator
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization Department of Pathology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s13601-020-00362-7
dc.relation.issn 2045-7022
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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