Pneumococcal carriage among children aged 4-12 years in Angola 4 years after the introduction of a pneumococcal conjugate vaccine

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Udden , F , Filipe , M , Slotved , H-C , Yamba-Yamba , L , Fuursted , K , Kuatoko , P P , Larsson , M , Bjurgert , J , Mansson , V , Pelkonen , T , Reimer , A & Riesbeck , K 2020 , ' Pneumococcal carriage among children aged 4-12 years in Angola 4 years after the introduction of a pneumococcal conjugate vaccine ' , Vaccine , vol. 38 , no. 50 , pp. 7928-7937 . https://doi.org/10.1016/j.vaccine.2020.10.060

Title: Pneumococcal carriage among children aged 4-12 years in Angola 4 years after the introduction of a pneumococcal conjugate vaccine
Author: Udden, Fabian; Filipe, Matuba; Slotved, Hans-Christian; Yamba-Yamba, Linda; Fuursted, Kurt; Kuatoko, Palmira Pintar; Larsson, Mans; Bjurgert, Jonas; Mansson, Viktor; Pelkonen, Tuula; Reimer, Ake; Riesbeck, Kristian
Contributor: University of Helsinki, HUS Children and Adolescents
Date: 2020-11-25
Language: eng
Number of pages: 10
Belongs to series: Vaccine
ISSN: 0264-410X
URI: http://hdl.handle.net/10138/324447
Abstract: Children in Angola are affected by a high burden of disease caused by pneumococcal infections. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the childhood immunization programme in 2013 but the serotype distribution of Streptococcus pneumoniae and antimicrobial susceptibility patterns are unknown. We did a cross-sectional nasopharyngeal carriage study in Luanda and Saurimo, Angola (PCV13 3rd dose coverage 67% and 84%, respectively) during November to December 2017 comprising 940 children aged 4-12 years. The main objective was to assess vaccine serotype coverage and antimicrobial susceptibility rates for S. pneumoniae. Our secondary aim was to characterize colonizinig strains of Haemophilus influenzae and Moraxella catarrhalis. Pneumococcal colonization was found in 35% (95% CI 32-39%) of children (n = 332), with 41% of serotypes covered by PCV13. The most common serotypes were 3 (8%), 18C (6%), 23F (6%), 11A (6%), 34 (6%), 19F (5%) and 16 (5%). Carriage of H. influenzae and M. catarrhalis was detected in 13% (95% CI 11-15%) and 15% (95% CI 13-17%) of children, respectively. Non-susceptibility to penicillin was common among pneumococci (40%), particularly among PCV13-included serotypes (50% vs. 33%; p = 0.003), although the median minimal inhibitory concentration was low (0.19 mg/mL, IQR 0.13-0.25 mg/mL). Most pneumococci and H. influenzae were susceptible to amoxicillin (99% and 88%, respectively). Furthermore, resistance to trimethoprim-sulfamethoxazole was>70% among all three species. Multidrug-resistant pneumococci (non-susceptible to > 3 antibiotics; 7% [n = 24]) were further studied with whole genome sequencing to investigate clonality as an underlying cause for this phenotype. No clearly dominating clone(s) were, however, detected. The results indicate that continued use of PCV13 may have positive direct and herd effects on pneumococcal infections in Angola as carriage of vaccine serotypes was common in the non-vaccinated age group. Finally, amoxicillin is assessed to be a feasible empirical treatment of respiratory tract infections in Angola. (C) 2020 The Author(s). Published by Elsevier Ltd.
Subject: Angola
Haemophilus influenzae
Moraxella catarrhalis
Nasopharyngeal colonization
Pneumococcal conjugate vaccine
Streptococcus pneumoniae
HAEMOPHILUS-INFLUENZAE
STREPTOCOCCUS-PNEUMONIAE
NASOPHARYNGEAL CARRIAGE
B DISEASE
IDENTIFICATION
COLONIZATION
13-VALENT
LOCUS
TIME
ERA
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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