Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women : A Cross-Sectional Study

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Värri , M , Niskanen , L , Tuomainen , T-P , Honkanen , R , Kröger , H & Tuppurainen , M T 2020 , ' Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women : A Cross-Sectional Study ' , Vascular Health and Risk Management , vol. 16 , pp. 515-524 . https://doi.org/10.2147/VHRM.S279028

Title: Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women : A Cross-Sectional Study
Author: Värri, Miika; Niskanen, Leo; Tuomainen, Tomi-Pekka; Honkanen, Risto; Kröger, Heikki; Tuppurainen, Marjo T.
Contributor: University of Helsinki, HUS Abdominal Center
Date: 2020
Language: eng
Number of pages: 10
Belongs to series: Vascular Health and Risk Management
ISSN: 1176-6344
URI: http://hdl.handle.net/10138/324449
Abstract: Purpose: Atherosclerosis (AS) and osteoporosis (OP) are common causes of morbidity and mortality in postmenopausal women and are connected via an unknown mechanistic link. Metabolite profiling of blood samples may allow the identification of new biomarkers and pathways for this enigmatic association. Patients and Methods: We studied the difference in 148 metabolite levels from serum samples in postmenopausal women with AS and OP compared with those in healthy participants in this cross-sectional study. Quantitative AS was assessed by carotid artery intima-media thickness (cIMT) and carotid artery calcifications (CACs) by ultrasound, as well as OP by femoral neck (FN) bone mineral density (BMD) and 148 metabolic measures with high-throughput proton (H-1) nuclear magnetic resonance (NMR) in serum samples from 280 postmenopausal (PM) women. Subjects were a randomly selected subsample from the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study. The final study population included the following groups: OP with CAC (n=16, group I), non-OP with no CAC (n=59, group II), high cIMT tertile with OP (n=11, group III) and low cIMT tertile without OP (n=48, group IV). Results: There were differences in several metabolite levels between groups I and II. The acetate level was lower in group I compared to that in group II (group I mean +/- SD: 0.033 +/- 0.0070; group II: 0.041 +/- 0.014, CI95%: 0.018.0.15, p=0.014). The result was similar with diacylglycerol (p=0.002), leucine (p=0.031), valine (p=0.022) and several very low-density lipoprotein (VLDL) metabolite levels, which were lower in group I compared to those in group II. However, no associations were found in adjusted analyses with total body (TB) fat mass (FM), age and statin use (p>0.05). Conclusion: Our novel study found differences in the metabolite profiling of altered amino acid and lipoprotein metabolism in participants with OP and AS compared with those in healthy women. The causative mechanisms remain unknown and further studies are needed.
Subject: metabolomics
carotid artery calcification
postmenopausal women
osteoporosis
carotid intima-media thickness
acetate
BONE-MINERAL DENSITY
INTIMA-MEDIA THICKNESS
CORONARY-ARTERY CALCIFICATION
LIPOPROTEIN CHOLESTEROL
CARDIOVASCULAR-DISEASE
LIPID-LEVELS
FOLLOW-UP
RISK
DIET
ASSOCIATION
3121 General medicine, internal medicine and other clinical medicine
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