Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study

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Heiskanen , J S , Hernesniemi , J A , Ruohonen , S , Hutri-Kähönen , N , Kähönen , M , Jokinen , E , Tossavainen , P , Kallio , M , Laitinen , T , Lehtimäki , T , Viikari , J , Juonala , M , Nevalainen , J & Raitakari , O T 2021 , ' Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study ' , Annals of Medicine , vol. 53 , no. 1 , pp. 160-168 . https://doi.org/10.1080/07853890.2020.1849785

Title: Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study
Author: Heiskanen, Jarkko S.; Hernesniemi, Jussi A.; Ruohonen, Saku; Hutri-Kähönen, Nina; Kähönen, Mika; Jokinen, Eero; Tossavainen, Paivi; Kallio, Merja; Laitinen, Tomi; Lehtimäki, Terho; Viikari, Jorma; Juonala, Markus; Nevalainen, Jaakko; Raitakari, Olli T.
Contributor: University of Helsinki, HUS Children and Adolescents
Date: 2021-01-01
Language: eng
Number of pages: 9
Belongs to series: Annals of Medicine
ISSN: 0785-3890
URI: http://hdl.handle.net/10138/324453
Abstract: Background Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood. Methods We used longitudinal data from a 31-year follow-up to examine the associations between early-life (between ages 6-18) BMI and SPB on LVM in an adult population (N = 1864, aged 34-49). The burden of early-life BMI and SBP was defined as area under the curve. Results After accounting for contemporary adult determinants of LVM, early-life BMI burden associated significantly with LVM (3.61 g/SD increase in early-life BMI; [1.94 - 5.28], p <0.001). Overweight in early-life (age- and sex-specific BMI values corresponding to adult BMI > 25 kg/m(2)) associated with 4.7% (2.5-6.9%, p <0.0001) higher LVM regardless of BMI status in adulthood. Overweight in early-life combined with obesity in adulthood (BMI > 30kg/m(2)) resulted in a 21% (17.3-32.9%, p <0.0001) increase in LVM. Higher early-life BMI was associated with a risk of developing eccentric hypertrophy. The burden of early-life SPB was not associated with adult LVM or left ventricular remodeling. Conclusions High BMI in early-life confers a sustained effect on LVM and the risk for eccentric hypertrophy independently of adulthood risk factors. KEY MESSAGES Excess in BMI in early-life has an independent effect on LVM and the risk of developing eccentric hypertrophy regardless of overweight status in adulthood. Systolic blood pressure levels in early-life did not have an independent effect on LVM or LV remodeling. The clinical implication of this study is that primary prevention of obesity in early-life may prevent the development of high LVM and eccentric hypertrophy.
Subject: Left ventricular mass
body mass index
blood pressure
risk factor
epidemiology
3121 General medicine, internal medicine and other clinical medicine
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