ENDOCRINOLOGY IN THE TIME OF COVID-19 Clinical management of neuroendocrine neoplasms (NENs)

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Casey , R T , Valk , G D , Schalin-Jäntti , C , Grossman , A B & Thakker , R V 2020 , ' ENDOCRINOLOGY IN THE TIME OF COVID-19 Clinical management of neuroendocrine neoplasms (NENs) ' , European Journal of Endocrinology , vol. 183 , no. 2 , pp. G79-G88 . https://doi.org/10.1530/EJE-20-0424

Title: ENDOCRINOLOGY IN THE TIME OF COVID-19 Clinical management of neuroendocrine neoplasms (NENs)
Author: Casey, Ruth T.; Valk, Gerlof D.; Schalin-Jäntti, Camilla; Grossman, Ashley B.; Thakker, Rajesh V.
Contributor organization: HUS Abdominal Center
Endokrinologian yksikkö
University of Helsinki
Helsinki University Hospital Area
Date: 2020-08
Language: eng
Number of pages: 10
Belongs to series: European Journal of Endocrinology
ISSN: 0804-4643
DOI: https://doi.org/10.1530/EJE-20-0424
URI: http://hdl.handle.net/10138/324471
Abstract: In viral pandemics, most specifically Covid-19, many patients with neuroendocrine neoplasms (NENs), including phaeochromocytomas, paragangliomas and medullary thyroid carcinoma, may develop Covid-19 in a mild or severe form, or be concerned about the influence of viral infection relative to their anti-tumoral therapy. In general, newly presenting patients should be assessed, and patients recently receiving chemotherapy, targeted therapy or radionuclide therapy, or showing tumour growth, should be closely followed. For previously diagnosed patients, who have indolent disease, some delay in routine follow-up or treatment may not be problematic. However, patients developing acute secretory syndromes due to functional neuroendocrine neoplasms (such as of the pancreas, intestine or lung), phaeochromocytomas and paragangliomas, will require prompt treatment. Patients with life-threatening Covid-19-related symptoms should be urgently treated and long-term anti-tumoral treatments may be temporarily delayed. In patients with especially aggressive NENs, a careful judgement should be made regarding the severity of any Covid-19 illness, tumour grade, and the immunosuppressant effects of any planned chemotherapy, immunotherapy (e.g. interferon-alpha), targeted therapy or related treatment. In other cases, especially patients with completely resected NENs, or who are under surveillance for a genetic disorder, a telephone or delayed consultation may be in order, balancing the risk of a delay against that of the possible development of Covid-19.
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion

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