Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era

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Räisänen , I T , Umeizudike , K A , Pärnänen , P , Heikkilä , P , Tervahartiala , T , Nwhator , S O , Grigoriadis , A , Sakellari , D & Sorsa , T 2020 , ' Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era ' , Medical Hypotheses , vol. 144 , 110276 . https://doi.org/10.1016/j.mehy.2020.110276

Title: Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era
Author: Räisänen, Ismo T.; Umeizudike, Kehinde A.; Pärnänen, Pirjo; Heikkilä, Pia; Tervahartiala, Taina; Nwhator, Solomon O.; Grigoriadis, Andreas; Sakellari, Dimitra; Sorsa, Timo
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Department of Oral and Maxillofacial Diseases
Date: 2020-11
Language: eng
Number of pages: 6
Belongs to series: Medical Hypotheses
ISSN: 0306-9877
URI: http://hdl.handle.net/10138/324505
Abstract: Periodontal disease is a chronic multifactorial infectious and inflammatory disease associated with several chronic systemic diseases, such as diabetes, cardiovascular diseases (CVD), chronic obstructive pulmonary disease, hypertension, Alzheimer's disease and so on. These same systemic diseases have been associated with severe COVID-19 infections. Several recent studies have suggested hypotheses for the potential association between periodontal disease and severe COVID-19. Periodontal disease is also one of the most prevalent diseases globally. All this supports the importance of good oral health, also in the COVID-19 era. Thus, new strategies and approaches to identify patients at risk of periodontal disease could be beneficial to enhance secondary prevention, especially if targeted to COVID-19 risk groups. Diagnostic biomarkers for periodontal disease have been researched extensively. Potential biomarkers in oral fluid with currently available rapid non-invasive point-of-care technology, such as aMMP-8, could help to extend screening and identification of patients at risk for periodontal disease also to situations and places where professional dental expertise and equipment are limited or unavailable. i.e., nursing and care homes, and rural and distant places. The oral fluid point-of-care technologies could also be useful in the hands of medical professionals (diabetes, CVD, etc.) to identify patients at risk for undiagnosed periodontal disease and to refer them to a dentist for examination and evaluation. Finally, if there is a causality between periodontal disease and severe COVID-19 infections, these point-of-care oral fluid biomarker technologies could possibly also help in the assessment of the risk of deterioration and complications.
Subject: Periodontitis
Prevention
Point-of-care testing
Teledentistry
aMMP-8
COVID-19
GINGIVAL CREVICULAR FLUID
MATRIX METALLOPROTEINASE-8
NEUTROPHIL COLLAGENASE
MMP-8
ASSOCIATION
HYGIENE
TELEDENTISTRY
PATHOGENESIS
DIAGNOSIS
MORTALITY
313 Dentistry
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