Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits

Show full item record



Permalink

http://hdl.handle.net/10138/324515

Citation

Meri , S & Haapasalo , K 2020 , ' Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits ' , Frontiers in Immunology , vol. 11 , 611830 . https://doi.org/10.3389/fimmu.2020.611830

Title: Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits
Author: Meri, Seppo; Haapasalo, Karita
Contributor: University of Helsinki, HUSLAB
University of Helsinki, Department of Bacteriology and Immunology
Date: 2020-12-08
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/324515
Abstract: Complement-mediated inflammation or dysregulation in lipid metabolism are associated with the pathogenesis of several diseases. These include age-related macular degeneration (AMD), C3 glomerulonephritis (C3GN), dense deposit disease (DDD), atherosclerosis, and Alzheimer's disease (AD). In all these diseases, formation of characteristic lipid-rich deposits is evident. Here, we will discuss molecular mechanisms whereby dysfunction of complement, and especially of its key regulator factor H, could be involved in lipid accumulation and related inflammation. The genetic associations to factor H polymorphisms, the role of factor H in the resolution of inflammation in lipid-rich deposits, modification of macrophage functions, and complement-mediated clearance of apoptotic and damaged cells indicate that the function of factor H is crucial in limiting inflammation in these diseases.
Subject: apoE
C-reactive protein
adiponectin
HDL
amyloid-beta
protein
C-REACTIVE PROTEIN
LOW-DENSITY-LIPOPROTEIN
POLYANION BINDING-SITE
APOLIPOPROTEIN-E
ALTERNATIVE PATHWAY
MACULAR DEGENERATION
ALZHEIMERS-DISEASE
Y402H POLYMORPHISM
APOPTOTIC CELLS
INNATE IMMUNITY
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
fimmu_11_611830.pdf 1.894Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record