Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

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http://hdl.handle.net/10138/324533

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Frejborg , E , Salo , T & Salem , A 2020 , ' Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis ' , International Journal of Molecular Sciences . https://doi.org/10.3390/ijms21239246

Titel: Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis
Författare: Frejborg, Ellen; Salo, Tuula; Salem, Abdelhakim
Medarbetare: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUSLAB
University of Helsinki, Clinicum
Datum: 2020-12-03
Språk: eng
Sidantal: 17
Tillhör serie: International Journal of Molecular Sciences
ISSN: 1422-0067
Permanenta länken (URI): http://hdl.handle.net/10138/324533
Abstrakt: The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes.
Subject: 1182 Biochemistry, cell and molecular biology
3111 Biomedicine
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