Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

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dc.contributor University of Helsinki, Department of Oral and Maxillofacial Diseases en
dc.contributor University of Helsinki, HUSLAB en
dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Frejborg, Ellen
dc.contributor.author Salo, Tuula
dc.contributor.author Salem, Abdelhakim
dc.date.accessioned 2021-01-14T11:29:02Z
dc.date.available 2021-01-14T11:29:02Z
dc.date.issued 2020-12-03
dc.identifier.citation Frejborg , E , Salo , T & Salem , A 2020 , ' Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis ' , International Journal of Molecular Sciences . https://doi.org/10.3390/ijms21239246 en
dc.identifier.issn 1422-0067
dc.identifier.other PURE: 156667396
dc.identifier.other PURE UUID: 2d0abb7e-c4ac-4aff-89cf-bf0e0b4fc816
dc.identifier.other WOS: 000597604800001
dc.identifier.other ORCID: /0000-0001-6039-0088/work/86937888
dc.identifier.other ORCID: /0000-0002-9455-3823/work/86940237
dc.identifier.uri http://hdl.handle.net/10138/324533
dc.description.abstract The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof International Journal of Molecular Sciences
dc.rights en
dc.subject 1182 Biochemistry, cell and molecular biology en
dc.subject 3111 Biomedicine en
dc.title Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis en
dc.type Review Article
dc.identifier.doi https://doi.org/10.3390/ijms21239246
dc.type.uri info:eu-repo/semantics/other
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