SUMMIT Steering Comm , CARDIOGRAMplusC4D Steering Comm , van Zuydam , N R , Ladenvall , C , Vlachopoulou , E , Perola , M , Sinisalo , J , Salomaa , V , Groop , L & Ripatti , S 2020 , ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ' , Circulation-Genomic and precision medicine , vol. 13 , no. 6 , e002769 , pp. 640-648 . https://doi.org/10.1161/CIRCGEN.119.002769
Title: | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
Author: | SUMMIT Steering Comm; CARDIOGRAMplusC4D Steering Comm; van Zuydam, Natalie R.; Ladenvall, Claes; Vlachopoulou, Efthymia; Perola, Markus; Sinisalo, Juha; Salomaa, Veikko; Groop, Leif; Ripatti, Samuli |
Contributor organization: | Transplantation Laboratory University of Helsinki Research Programs Unit CAMM - Research Program for Clinical and Molecular Metabolism Faculty of Medicine Department of Medicine Doctoral Programme in Clinical Research Clinicum HUS Heart and Lung Center Centre of Excellence in Complex Disease Genetics HUS Abdominal Center Institute for Molecular Medicine Finland Department of Public Health Samuli Olli Ripatti / Principal Investigator Complex Disease Genetics University Management Biostatistics Helsinki |
Date: | 2020-12 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | Circulation-Genomic and precision medicine |
ISSN: | 2574-8300 |
DOI: | https://doi.org/10.1161/CIRCGEN.119.002769 |
URI: | http://hdl.handle.net/10138/324535 |
Abstract: | BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D. |
Subject: |
blood pressure
coronary artery disease diabetes mellitus genome-wide association study risk factors GENOME-WIDE ASSOCIATION CARDIOVASCULAR-DISEASE COMMON VARIANTS GLYCEMIC TRAITS HEART-DISEASE LOCI PATHWAYS GLUCOSE RISK INSIGHTS 3121 General medicine, internal medicine and other clinical medicine 3111 Biomedicine 1184 Genetics, developmental biology, physiology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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