Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

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SUMMIT Steering Comm , CARDIOGRAMplusC4D Steering Comm , van Zuydam , N R , Ladenvall , C , Vlachopoulou , E , Perola , M , Sinisalo , J , Salomaa , V , Groop , L & Ripatti , S 2020 , ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ' , Circulation-Genomic and precision medicine , vol. 13 , no. 6 , e002769 , pp. 640-648 . https://doi.org/10.1161/CIRCGEN.119.002769

Title: Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Author: SUMMIT Steering Comm; CARDIOGRAMplusC4D Steering Comm; van Zuydam, Natalie R.; Ladenvall, Claes; Vlachopoulou, Efthymia; Perola, Markus; Sinisalo, Juha; Salomaa, Veikko; Groop, Leif; Ripatti, Samuli
Contributor organization: Transplantation Laboratory
University of Helsinki
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Department of Medicine
Doctoral Programme in Clinical Research
Clinicum
HUS Heart and Lung Center
Centre of Excellence in Complex Disease Genetics
HUS Abdominal Center
Institute for Molecular Medicine Finland
Department of Public Health
Samuli Olli Ripatti / Principal Investigator
Complex Disease Genetics
University Management
Biostatistics Helsinki
Date: 2020-12
Language: eng
Number of pages: 9
Belongs to series: Circulation-Genomic and precision medicine
ISSN: 2574-8300
DOI: https://doi.org/10.1161/CIRCGEN.119.002769
URI: http://hdl.handle.net/10138/324535
Abstract: BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
Subject: blood pressure
coronary artery disease
diabetes mellitus
genome-wide association study
risk factors
GENOME-WIDE ASSOCIATION
CARDIOVASCULAR-DISEASE
COMMON VARIANTS
GLYCEMIC TRAITS
HEART-DISEASE
LOCI
PATHWAYS
GLUCOSE
RISK
INSIGHTS
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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