Osteoid Metaplasia in Femoral Artery Plaques Is Associated With the Clinical Severity of Lower Extremity Artery Disease in Men

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dc.contributor.author Laivuori, Mirjami
dc.contributor.author Tolva, Johanna
dc.contributor.author Lokki, A. Inkeri
dc.contributor.author Linder, Nina
dc.contributor.author Lundin, Johan
dc.contributor.author Paakkanen, Riitta
dc.contributor.author Albäck, Anders
dc.contributor.author Venermo, Maarit
dc.contributor.author Mäyränpää, Mikko I.
dc.contributor.author Lokki, Marja-Liisa
dc.contributor.author Sinisalo, Juha
dc.date.accessioned 2021-01-15T09:08:01Z
dc.date.available 2021-01-15T09:08:01Z
dc.date.issued 2020-12-10
dc.identifier.citation Laivuori , M , Tolva , J , Lokki , A I , Linder , N , Lundin , J , Paakkanen , R , Albäck , A , Venermo , M , Mäyränpää , M I , Lokki , M-L & Sinisalo , J 2020 , ' Osteoid Metaplasia in Femoral Artery Plaques Is Associated With the Clinical Severity of Lower Extremity Artery Disease in Men ' , Frontiers in cardiovascular medicine , vol. 7 , 594192 . https://doi.org/10.3389/fcvm.2020.594192
dc.identifier.other PURE: 157223238
dc.identifier.other PURE UUID: b4b3d4cd-5e27-43f9-bfc5-0bb49369ccfb
dc.identifier.other Bibtex: 10.3389/fcvm.2020.594192
dc.identifier.other WOS: 000601260100001
dc.identifier.other ORCID: /0000-0003-3930-0513/work/86936248
dc.identifier.other ORCID: /0000-0003-4397-8415/work/86938361
dc.identifier.other ORCID: /0000-0002-0877-9640/work/86940653
dc.identifier.other ORCID: /0000-0002-0169-5137/work/86940902
dc.identifier.uri http://hdl.handle.net/10138/324653
dc.description.abstract Lamellar metaplastic bone, osteoid metaplasia (OM), is found in atherosclerotic plaques, especially in the femoral arteries. In the carotid arteries, OM has been documented to be associated with plaque stability. This study investigated the clinical impact of OM load in femoral artery plaques of patients with lower extremity artery disease (LEAD) by using a deep learning-based image analysis algorithm. Plaques from 90 patients undergoing endarterectomy of the common femoral artery were collected and analyzed. After decalcification and fixation, 4-μm-thick longitudinal sections were stained with hematoxylin and eosin, digitized, and uploaded as whole-slide images on a cloud-based platform. A deep learning-based image analysis algorithm was trained to analyze the area percentage of OM in whole-slide images. Clinical data were extracted from electronic patient records, and the association with OM was analyzed. Fifty-one (56.7%) sections had OM. Females with diabetes had a higher area percentage of OM than females without diabetes. In male patients, the area percentage of OM inversely correlated with toe pressure and was significantly associated with severe symptoms of LEAD including rest pain, ulcer, or gangrene. According to our results, OM is a typical feature of femoral artery plaques and can be quantified using a deep learning-based image analysis method. The association of OM load with clinical features of LEAD appears to differ between male and female patients, highlighting the need for a gender-specific approach in the study of the mechanisms of atherosclerotic disease. In addition, the role of plaque characteristics in the treatment of atherosclerotic lesions warrants further consideration in the future. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Frontiers in cardiovascular medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject atherosclerosis
dc.subject lower extremity artery disease (LEAD)
dc.subject osteoid metaplasia
dc.subject machine learning
dc.subject digital pathology
dc.subject histology
dc.subject artificial intelligence
dc.title Osteoid Metaplasia in Femoral Artery Plaques Is Associated With the Clinical Severity of Lower Extremity Artery Disease in Men en
dc.type Article
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Clinicum
dc.contributor.organization Verisuonikirurgian yksikkö
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization University of Helsinki
dc.contributor.organization Transplantation Laboratory
dc.contributor.organization Department of Pathology
dc.contributor.organization Medicum
dc.contributor.organization Kardiologian yksikkö
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization TRIMM - Translational Immunology Research Program
dc.contributor.organization Research Programs Unit
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.contributor.organization Johan Edvard Lundin / Principal Investigator
dc.contributor.organization HUSLAB
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fcvm.2020.594192
dc.relation.issn 2297-055X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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