Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis : A Nordic Multicenter Study

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Auraen , H , Durheim , M T , Dellgren , G , Hammainen , P , Larsson , H , Geiran , O , Schultz , H H L , Leuckfeld , I , Iversen , M , Fiane , A & Holm , A M 2019 , ' Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis : A Nordic Multicenter Study ' , Transplantation , vol. 103 , no. 4 , pp. 807-814 . https://doi.org/10.1097/TP.0000000000002402

Title: Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis : A Nordic Multicenter Study
Author: Auraen, Henrik; Durheim, Michael Thomas; Dellgren, Göran; Hammainen, Pekka; Larsson, Hillevi; Geiran, Odd; Schultz, Hans Henrik Lawaetz; Leuckfeld, Inga; Iversen, Martin; Fiane, Arnt; Holm, Are Martin
Contributor: University of Helsinki, Department of Surgery
Date: 2019-04
Language: eng
Number of pages: 8
Belongs to series: Transplantation
ISSN: 0041-1337
URI: http://hdl.handle.net/10138/324664
Abstract: Background. Organs from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are unclear. This multicenter study reviews all bilateral lung transplantations (BLTx) from donors 55 years or older stratified by recipient diagnosis and compares outcomes with transplantations from younger donors. Methods. All BLTx recipients (excluding retransplantation) at 5 Scandiatransplant centers between 2000 and 2013 were included (n = 913). Recipients were stratified to diagnosis groups including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and "other." Intensive care unit (ICU) length of stay (LOS) and survival were assessed. Results. Overall, there was no difference in survival among patients transplanted from donors 55 years or older compared with younger donors. However, in CF recipients, donor age 55 years or older was associated with inferior survival (P = 0.014), and this remained significant in a multivariate model (hazard ratio, 5.0; 95% confidence interval, 1.8-14.1; P = 0.002). There was no significant effect of donor age on survival in recipients with COPD, ILD, or in the "other" group in multivariate models. Utilization of older donors was associated with increased ICU LOS for recipients with CF and ILD, but not in the COPD or "other" group. Conclusions. The BLTx recipients with CF had inferior survival and longer ICU LOS when receiving organs from donors 55 years or older. Recipients with COPD, ILD, or in the "other" group did not have inferior survival in multivariate models.
Subject: OLDER
POOL
3126 Surgery, anesthesiology, intensive care, radiology
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