Seipin-Mediated Contacts as Gatekeepers of Lipid Flux at the Endoplasmic Reticulum–Lipid Droplet Nexus 

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dc.contributor University of Helsinki, STEMM - Stem Cells and Metabolism Research Program en
dc.contributor University of Helsinki, Faculty Common Matters en
dc.contributor University of Helsinki, STEMM - Stem Cells and Metabolism Research Program en
dc.contributor.author Salo, Veijo T.
dc.contributor.author Hölttä-Vuori, Maarit
dc.contributor.author Ikonen, Elina
dc.date.accessioned 2021-01-19T05:12:02Z
dc.date.available 2021-01-19T05:12:02Z
dc.date.issued 2020
dc.identifier.citation Salo , V T , Hölttä-Vuori , M & Ikonen , E 2020 , ' Seipin-Mediated Contacts as Gatekeepers of Lipid Flux at the Endoplasmic Reticulum–Lipid Droplet Nexus  ' , Contact , vol. 3 . https://doi.org/10.1177/2515256420945820 en
dc.identifier.issn 2515-2564
dc.identifier.other PURE: 159008282
dc.identifier.other PURE UUID: be59c50a-91fb-4dc8-8b79-19440599189e
dc.identifier.other Bibtex: doi:10.1177/2515256420945820
dc.identifier.other ORCID: /0000-0002-0488-4486/work/87348241
dc.identifier.other ORCID: /0000-0001-8382-1135/work/87348654
dc.identifier.other ORCID: /0000-0002-6991-2142/work/87350865
dc.identifier.uri http://hdl.handle.net/10138/324844
dc.description.abstract Lipid droplets (LDs) are dynamic cellular hubs of lipid metabolism. While LDs contact a plethora of organelles, they have the most intimate relationship with the endoplasmic reticulum (ER). Indeed, LDs are initially assembled at specialized ER subdomains, and recent work has unraveled an increasing array of proteins regulating ER-LD contacts. Among these, seipin, a highly conserved lipodystrophy protein critical for LD growth and adipogenesis, deserves special attention. Here, we review recent insights into the role of seipin in LD biogenesis and as a regulator of ER-LD contacts. These studies have also highlighted the evolving concept of ER and LDs as a functional continuum for lipid partitioning and pinpointed a role for seipin at the ER-LD nexus in controlling lipid flux between these compartments. fi
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof Contact
dc.rights en
dc.subject 1182 Biochemistry, cell and molecular biology en
dc.title Seipin-Mediated Contacts as Gatekeepers of Lipid Flux at the Endoplasmic Reticulum–Lipid Droplet Nexus  en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1177/2515256420945820
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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