Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

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Elsilä , L V , Korhonen , N , Hyytiä , P & Korpi , E R 2020 , ' Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task ' , Frontiers in Pharmacology , vol. 11 , 602770 . https://doi.org/10.3389/fphar.2020.602770

Title: Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task
Author: Elsilä, Lauri V.; Korhonen, Nuppu; Hyytiä, Petri; Korpi, Esa R.
Contributor: University of Helsinki, Medicum
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Pharmacology
Date: 2020-12-03
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Pharmacology
ISSN: 1663-9812
URI: http://hdl.handle.net/10138/324846
Abstract: While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient. In particular, there are gaps in knowledge on executive functions and goal-directed behaviors both in humans and in commonly used animal models. The effects of acute doses of psychedelic lysergic acid diethylamide (LSD) on reward-driven decision making were explored using the mouse version of the Iowa Gambling Task. A total of 15 mice were trained to perform in a touch-screen adaptation of the rodent version of the Iowa Gambling Task, after which single acute doses of LSD (0.025, 0.1, 0.2, 0.4 mg/kg), serotonin 2A receptor-selective agonist 25CN-NBOH (1.5 mg/kg), d-amphetamine (2.0 mg/kg), and saline were administered before the trial. 25CN-NBOH and the three lowest doses of LSD showed no statistically significant changes in option selection or in general functioning during the gambling task trials. The highest dose of LSD (0.4 mg/kg) significantly decreased premature responding and increased the omission rate, but had no effect on option selection in comparison with the saline control. Amphetamine significantly decreased the correct responses and premature responding while increasing the omission rate. In conclusion, mice can perform previously learned, reward-driven decision-making tasks while under the acute influence of LSD at a commonly used dose range.
Subject: 3111 Biomedicine
Pharmacology
lysergic acid diethylamide
psychedelic
hallucinogen
Iowa gambling task
decision-making
executive functions
25CN-NBOH
5-HT2C RECEPTOR ANTAGONISTS
PLACE PREFERENCE
DOUBLE-BLIND
LSD
PSILOCYBIN
BEHAVIOR
SEROTONIN
RAT
IMPULSIVITY
DOPAMINE
3112 Neurosciences
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