Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds

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Pohjanvirta , R & Viluksela , M 2020 , ' Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds ' , International Journal of Molecular Sciences , vol. 21 , no. 7 , 2342 . https://doi.org/10.3390/ijms21072342

Title: Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds
Author: Pohjanvirta, Raimo; Viluksela, Matti
Contributor: University of Helsinki, Food Hygiene and Environmental Health
Date: 2020-04
Language: eng
Number of pages: 6
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/324857
Abstract: Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose canonical signaling pathway has been unveiled in fair detail. The alternative (non-genomic) pathways are much more obscure. AHR has also proven to be a master regulator of numerous physiological phenomena, which has led to the search of selective AHR modulators with low toxicity. Papers of this Special Issue address the developmental toxicity of dioxins and related compounds as well as selective modulators of AHR and both its canonical and alternative signaling pathways. In addition, new optical and stereoscopic methods for the detection of dioxins are presented. As a whole, this Special Issue provides an up-to-date view on a wide variety of aspects related to dioxin toxicity mechanisms from both original research articles and reviews.
Subject: 2
3
7
8-Tetrachlorodibenzo-p-dioxin
TCDD
dioxins
halogenated aromatic hydrocarbons
polycyclic aromatic hydrocarbons
aryl hydrocarbon receptor
toxicity mechanisms
developmental toxicity
MONO-ADP-RIBOSYLTRANSFERASE
RECEPTOR
2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
TIPARP
1182 Biochemistry, cell and molecular biology
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