Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/324857

Lähdeviite

Pohjanvirta , R & Viluksela , M 2020 , ' Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds ' , International Journal of Molecular Sciences , vol. 21 , no. 7 , 2342 . https://doi.org/10.3390/ijms21072342

Julkaisun nimi: Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds
Tekijä: Pohjanvirta, Raimo; Viluksela, Matti
Tekijän organisaatio: Food Hygiene and Environmental Health
Helsinki One Health (HOH)
Raimo Pohjanvirta / Principal Investigator
Päiväys: 2020-04
Kieli: eng
Sivumäärä: 6
Kuuluu julkaisusarjaan: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI-tunniste: https://doi.org/10.3390/ijms21072342
URI: http://hdl.handle.net/10138/324857
Tiivistelmä: Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose canonical signaling pathway has been unveiled in fair detail. The alternative (non-genomic) pathways are much more obscure. AHR has also proven to be a master regulator of numerous physiological phenomena, which has led to the search of selective AHR modulators with low toxicity. Papers of this Special Issue address the developmental toxicity of dioxins and related compounds as well as selective modulators of AHR and both its canonical and alternative signaling pathways. In addition, new optical and stereoscopic methods for the detection of dioxins are presented. As a whole, this Special Issue provides an up-to-date view on a wide variety of aspects related to dioxin toxicity mechanisms from both original research articles and reviews.
Avainsanat: 2
3
7
8-Tetrachlorodibenzo-p-dioxin
TCDD
dioxins
halogenated aromatic hydrocarbons
polycyclic aromatic hydrocarbons
aryl hydrocarbon receptor
toxicity mechanisms
developmental toxicity
MONO-ADP-RIBOSYLTRANSFERASE
RECEPTOR
2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
TIPARP
1182 Biochemistry, cell and molecular biology
Vertaisarvioitu: Ei
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
ijms_21_02342.pdf 196.8KB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot