Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds

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Pohjanvirta , R & Viluksela , M 2020 , ' Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds ' , International Journal of Molecular Sciences , vol. 21 , no. 7 , 2342 .

Julkaisun nimi: Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds
Tekijä: Pohjanvirta, Raimo; Viluksela, Matti
Tekijän organisaatio: Food Hygiene and Environmental Health
Helsinki One Health (HOH)
Raimo Pohjanvirta / Principal Investigator
Päiväys: 2020-04
Kieli: eng
Sivumäärä: 6
Kuuluu julkaisusarjaan: International Journal of Molecular Sciences
ISSN: 1422-0067
Tiivistelmä: Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose canonical signaling pathway has been unveiled in fair detail. The alternative (non-genomic) pathways are much more obscure. AHR has also proven to be a master regulator of numerous physiological phenomena, which has led to the search of selective AHR modulators with low toxicity. Papers of this Special Issue address the developmental toxicity of dioxins and related compounds as well as selective modulators of AHR and both its canonical and alternative signaling pathways. In addition, new optical and stereoscopic methods for the detection of dioxins are presented. As a whole, this Special Issue provides an up-to-date view on a wide variety of aspects related to dioxin toxicity mechanisms from both original research articles and reviews.
Avainsanat: 2
halogenated aromatic hydrocarbons
polycyclic aromatic hydrocarbons
aryl hydrocarbon receptor
toxicity mechanisms
developmental toxicity
1182 Biochemistry, cell and molecular biology
Vertaisarvioitu: Ei
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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