Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds

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dc.contributor.author Pohjanvirta, Raimo
dc.contributor.author Viluksela, Matti
dc.date.accessioned 2021-01-19T09:13:00Z
dc.date.available 2021-01-19T09:13:00Z
dc.date.issued 2020-04
dc.identifier.citation Pohjanvirta , R & Viluksela , M 2020 , ' Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds ' , International Journal of Molecular Sciences , vol. 21 , no. 7 , 2342 . https://doi.org/10.3390/ijms21072342
dc.identifier.other PURE: 159273763
dc.identifier.other PURE UUID: 6a5de1d9-413f-4cb2-ad5f-72b2f2264a0e
dc.identifier.other WOS: 000535574200084
dc.identifier.uri http://hdl.handle.net/10138/324857
dc.description.abstract Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose canonical signaling pathway has been unveiled in fair detail. The alternative (non-genomic) pathways are much more obscure. AHR has also proven to be a master regulator of numerous physiological phenomena, which has led to the search of selective AHR modulators with low toxicity. Papers of this Special Issue address the developmental toxicity of dioxins and related compounds as well as selective modulators of AHR and both its canonical and alternative signaling pathways. In addition, new optical and stereoscopic methods for the detection of dioxins are presented. As a whole, this Special Issue provides an up-to-date view on a wide variety of aspects related to dioxin toxicity mechanisms from both original research articles and reviews. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof International Journal of Molecular Sciences
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 2
dc.subject 3
dc.subject 7
dc.subject 8-Tetrachlorodibenzo-p-dioxin
dc.subject TCDD
dc.subject dioxins
dc.subject halogenated aromatic hydrocarbons
dc.subject polycyclic aromatic hydrocarbons
dc.subject aryl hydrocarbon receptor
dc.subject toxicity mechanisms
dc.subject developmental toxicity
dc.subject MONO-ADP-RIBOSYLTRANSFERASE
dc.subject RECEPTOR
dc.subject 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
dc.subject TIPARP
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds en
dc.type Editorial
dc.contributor.organization Food Hygiene and Environmental Health
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Raimo Pohjanvirta / Principal Investigator
dc.description.reviewstatus Non peer reviewed
dc.relation.doi https://doi.org/10.3390/ijms21072342
dc.relation.issn 1422-0067
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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