Retrospective four-dimensional magnetic resonance imaging of liver : Method development

Show full item record



Permalink

http://hdl.handle.net/10138/324860

Citation

Kavaluus , H , Seppälä , T , Koivula , L , Salli , E , Collan , J , Saarilahti , K & Tenhunen , M 2020 , ' Retrospective four-dimensional magnetic resonance imaging of liver : Method development ' , Journal of applied clinical medical physics , vol. 21 , no. 12 , pp. 304-313 . https://doi.org/10.1002/acm2.13108

Title: Retrospective four-dimensional magnetic resonance imaging of liver : Method development
Author: Kavaluus, Henna; Seppälä, Tiina; Koivula, Lauri; Salli, Eero; Collan, Juhani; Saarilahti, Kauko; Tenhunen, Mikko
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
Date: 2020-12
Language: eng
Number of pages: 10
Belongs to series: Journal of applied clinical medical physics
ISSN: 1526-9914
URI: http://hdl.handle.net/10138/324860
Abstract: Purpose of our research was to develop a four-dimensional (4D) magnetic resonance imaging (MRI) method of liver. Requirements of the method were to create a clinical procedure with acceptable imaging time and sufficient temporal and spatial accuracy. The method should produce useful planning image sets for stereotactic body radiation therapy delivery both during breath-hold and in free breathing. The purpose of the method was to improve the localization of liver metastasis. The method was validated with phantom tests. Imaging parameters were optimized to create a 4D dataset compressed to one respiratory cycle of the whole liver with clinically reasonable level of image contrast and artifacts. Five healthy volunteers were imaged with T2-weighted SSFSE research sequence. The respiratory surrogate signal was observed by the linear navigator interleaved with the anatomical liver images. The navigator was set on head-feet - direction on the superior surface of the liver to detect the edge of diaphragm. The navigator signal and 2D liver image data were retrospectively processed with a self-developed MATLAB algorithm. A deformable phantom for 4D imaging tests was constructed by combining deformable tissue-equivalent material and a commercial programmable motor unit of the 4D phantom with a clinically relevant range of deformation patterns. 4D Computed Tomography images were used as reference to validate the MRI protocol. The best compromise of reasonable accuracy and imaging time was found with 2D T2-weighted SSFSE imaging sequence using parameters: TR = 500-550 ms, images/slices = 20, slice thickness = 3 mm. Then, image processing with number of respiratory phases = 8 constructed accurate 4D images of liver. We have developed the 4D-MRI method visualizing liver motions three-dimensionally in one representative respiratory cycle. From phantom tests it was found that the spatial agreement to 4D-CT is within 2 mm that is considered sufficient for clinical applications.
Subject: liver
radiotherapy
retrospective 4D&#8208
MRI
SBRT
RADIATION-THERAPY
ORGAN MOTION
TUMOR MOTION
RADIOTHERAPY
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
acm2.13108.pdf 1.271Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record