Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients

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Airaksinen , L , Laurikka , P , Huhtala , H , Kurppa , K , Salmi , T , Saavalainen , P , Kaukinen , K & Lindfors , K 2020 , ' Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients ' , Nutrients , vol. 12 , no. 12 , 3775 . https://doi.org/10.3390/nu12123775

Title: Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients
Author: Airaksinen, Laura; Laurikka, Pilvi; Huhtala, Heini; Kurppa, Kalle; Salmi, Teea; Saavalainen, Päivi; Kaukinen, Katri; Lindfors, Katri
Contributor organization: Immunomics
Research Programs Unit
University of Helsinki
TRIMM - Translational Immunology Research Program
Date: 2020-12
Language: eng
Number of pages: 9
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu12123775
URI: http://hdl.handle.net/10138/324906
Abstract: The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients' response to a gluten-free diet. The final cohort included 605 carefully phenotyped non-related Finnish celiac disease patients grouped as having 0, 1 or 2 copies of HLA-DQ2.5. Clinical data at the time of diagnosis and during gluten-free diet were collected systematically from medical records and supplementary interviews. An increasing HLA-DQ2.5 dose effect was detected for celiac disease antibody positivity at diagnosis (p = 0.021) and for the presence of any first-degree relatives with celiac disease (p = 0.011 and p = 0.031, respectively). Instead, DQ2.5-negative patients were suffering most often from classical symptoms at diagnosis (p = 0.007 between HLA groups). In addition, during follow-up they were most often symptomatic despite a gluten-free diet (p = 0.002 between groups). Our results thus suggest that increasing HLA-DQ2.5 dose only has a minor effect on the clinical picture of celiac disease. However, HLA-DQ2.5-negative patients should not be overlooked in clinical practice and particular attention should be paid to this patient group during gluten-free diet.
Subject: celiac disease
HLA-DQ2
5
dose effect
clinical presentation
gluten-free diet
DUODENAL MICROBIOTA COMPOSITION
GLUTEN-FREE DIET
GASTROINTESTINAL SYMPTOMS
IGA
SUSCEPTIBILITY
ANTIBODIES
GENES
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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