Clinical aspects of heat-labile and heat-stable toxin-producing enterotoxigenic Escherichia coli : A prospective study among Finnish travellers

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Turunen , K , Antikainen , J , Lääveri , T , Kirveskari , J , Svennerholm , A-M & Kantele , A 2020 , ' Clinical aspects of heat-labile and heat-stable toxin-producing enterotoxigenic Escherichia coli : A prospective study among Finnish travellers ' , Travel medicine and infectious disease , vol. 38 , 101855 . https://doi.org/10.1016/j.tmaid.2020.101855

Title: Clinical aspects of heat-labile and heat-stable toxin-producing enterotoxigenic Escherichia coli : A prospective study among Finnish travellers
Author: Turunen, Katri; Antikainen, Jenni; Lääveri, Tinja; Kirveskari, Juha; Svennerholm, Ann-Mari; Kantele, Anu
Other contributor: University of Helsinki, Department of Medicine
University of Helsinki, HUSLAB
University of Helsinki, HUS Inflammation Center
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine







Date: 2020
Language: eng
Number of pages: 9
Belongs to series: Travel medicine and infectious disease
ISSN: 1477-8939
DOI: https://doi.org/10.1016/j.tmaid.2020.101855
URI: http://hdl.handle.net/10138/324924
Abstract: Background: Enterotoxigenic Escherichia coli (ETEC) is a major pathogen causing travellers' diarrhoea (TD) among visitors to low- and middle-income countries (LMIC). Scant data are available on rates of travel-acquired ETEC producing heat-labile (LT) and/or heat-stable (ST) toxin or its subtypes, STh (human) and STp (porcine) in various geographic regions, and on clinical pictures associated with each toxin. Methods: Using qPCR, we analysed LT, STh, and STp in stools positive for ETEC in a prospective study among 103 Finnish travellers visiting LMIC. They filled in questionnaires and provided stool samples before and after travel. We scrutinized geographic distribution of LT, STh, and STp ETEC findings, and association between these different ETEC subtypes and moderate/severe TD. Results: Among the 103 stool samples positive for ETEC toxins, the rate for LT was 76%, for STh 26%, and STp 41%. The rate for LT-only was 44%, for 5Th-only 6%, STp-only 16%, LT + STh 10%, LT + STp 15%, STh + STp 3%, and LT + STh + STp 8%. Findings varied by destination; the rates of LT, STh, and STp were 79%, 21%, and 57%, respectively, in Southern Asia (n = 14); 85%, 10%, and 20% in South-eastern Asia (n = 20); 84%, 13%, and 29% in Eastern Africa (n = 31); and 56%, 50%, and 63% in Western Africa (n = 32), respectively. Of travellers positive for LT, STh, and STp, 83%, 100%, and 88%, encountered TD; 35%, 55%, and 41% reported moderate/severe TD. STh was associated with moderate/severe TD. Conclusions: Toxin findings varied by destination; multiple toxins were commonly detected. Moderate/severe TD was reported most frequently by subjects with STh-ETEC.
Subject: ETEC
LT
ST
STh
STp
Travellers' diarrhoea
COLONIZATION FACTORS
YOUNG-CHILDREN
MILITARY PERSONNEL
DISEASE BURDEN
ACUTE DIARRHEA
US TRAVELERS
DOUBLE-BLIND
PATHOGENS
STRAINS
INFANTS
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
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