High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State : A PREVIEW Study

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Drummen , M , Tischmann , L , Gatta-Cherifi , B , Fogelholm , M , Raben , A , Adam , T C & Westerterp-Plantenga , M S 2020 , ' High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State : A PREVIEW Study ' , Journal of Nutrition , vol. 150 , no. 3 , pp. 458-463 . https://doi.org/10.1093/jn/nxz281

Title: High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State : A PREVIEW Study
Author: Drummen, Mathijs; Tischmann, Lea; Gatta-Cherifi, Blandine; Fogelholm, Mikael; Raben, Anne; Adam, Tanja C.; Westerterp-Plantenga, Margriet S.
Other contributor: University of Helsinki, Department of Food and Nutrition


Date: 2020-03
Language: eng
Number of pages: 6
Belongs to series: Journal of Nutrition
ISSN: 0022-3166
DOI: https://doi.org/10.1093/jn/nxz281
URI: http://hdl.handle.net/10138/324999
Abstract: Background: Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these adaptations are important for long-term weight loss and weight maintenance. Objective: The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) and the expected positive energy balance (EB) during weight maintenance after weight loss in participants with prediabetes in the postobese state. Methods: In 38 participants, the effects of 2 diets differing in protein/carbohydrate ratio on energy expenditure and respiratory quotient (RQ) were assessed during 48-h respiration chamber measurements similar to 34 mo after weight loss. Participants consumed a high-protein (HP) diet In = 20; 13 women/7 men; age: 64.0 +/- 6.2 y; BMI: 28.9 +/- 4.0 kg/m(2)) with 25:45:30% or a moderate-protein (MP) diet (n = 18; 9 women/9 men; age: 65.1 +/- 5.8 y; BMI: 29.0 +/- 3.8 kg/m(2)) with 15:55:30% of energy from protein:carbohydrate:fat. Predicted resting energy expenditure (REEp) was calculated based on fat-free mass and fat mass. AT was assessed by subtracting measured resting energy expenditure (REE) from REEp. The main outcomes included differences in components of energy expenditure, substrate oxidation, and AT between groups. Results: EB (MP = 0.2 +/- 0.9 MJ/d; HP = -0.5 +/- 0.9 MJ/d) and RO (MP = 0.84 +/- 0.02; HP = 0.82 +/- 0.02) were reduced and REE (MP: 73 +/- 0.2 MJ/d compared with HP: 78 +/- 0.2 MJ/d) was increased in the HP group compared with the MP group (P <0.05). REE was not different from REEp in the HP group, whereas REE was lower than REEp in the MP group (P <0.05). Furthermore, EB was positively related to AT (r(s) = 0.74; P <0.001) and RQ (r(s) = 0.47; P <0.01) in the whole group of participants. Conclusions: In conclusion, an HP diet compared with an MP diet led to a negative EB and counteracted AT similar to 34 mo after weight loss, in participants with prediabetes in the postobese state. These results indicate the relevance of compliance to an increased protein/carbohydrate ratio for long-term weight maintenance after weight loss.
Subject: protein
energy expenditure
adaptive thermogenesis
energy balance
weight loss
weight maintenance
obesity
BODY-WEIGHT
SUBSTRATE OXIDATION
RESPIRATION CHAMBER
INTAKE RESTRICTION
GENE-EXPRESSION
EXPENDITURE
CAPSAICIN
CARBOHYDRATE
METABOLISM
OBESITY
3143 Nutrition
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