Genetic dissection of Ni toxicity in a spring wheat diversity panel by using 90 K SNP array

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Safdar , L B , Almas , F , Rehman , A U , Umer , M J , Shah , S M A , Uddin , S , Ashfaq , S , Rahman , H U & Quraishi , U M 2020 , ' Genetic dissection of Ni toxicity in a spring wheat diversity panel by using 90 K SNP array ' , Current plant biology , vol. 24 , 100175 . https://doi.org/10.1016/j.cpb.2020.100175

Title: Genetic dissection of Ni toxicity in a spring wheat diversity panel by using 90 K SNP array
Author: Safdar, Luqman Bin; Almas, Fakhrah; Rehman, Attiq Ur; Umer, Muhammad Jawad; Shah, Syed Mashab Ali; Uddin, Siraj; Ashfaq, Shomaila; Rahman, Hamid Ur; Quraishi, Umar Masood
Contributor organization: Department of Agricultural Sciences
Date: 2020-12
Language: eng
Number of pages: 7
Belongs to series: Current plant biology
ISSN: 2214-6628
DOI: https://doi.org/10.1016/j.cpb.2020.100175
URI: http://hdl.handle.net/10138/325114
Abstract: Excess Ni intake has harmful implications on human health, which include chronic bronchitis, reduced lung function, and cancer of lung and nasal sinuses. Like other toxic metals, higher Ni accumulation in grains leads to excess intake by humans when the contaminated grains are consumed as food. There is little information about the genetic factors that regulate Ni uptake in plants. To investigate genetic architecture of Ni uptake in leaf and translocation to grain, we performed a genome-wide association study with genotyping from 90 K array in a historical bread wheat diversity panel from Pakistan. We observed that Ni toxicity caused more than 50 % reductions in biological yield and grain yield, other agronomic traits were also partly or severely affected. Genetic association study helped identify 23 SNP-trait associations involved in Ni uptake in leaf and translocation to grains. These 23 SNPs covered 15 genomic loci at chromosomes 1A, 2D, 3B, 4A and 4B of wheat. The favorable alleles of these SNPs were randomly distributed in subpopulations indicating no selection pressure for this trait during breeding improvement. These regions had 283 low-confidence and 248 high-confidence protein coding genes. Among these, 156 were annotated using databases of wheat and closely related grass species. Since there is no previous report on genetic information of Ni uptake and translocation, these results provide sufficient grounds for further research of candidate genes and varietal development.
Subject: Single nucleotide polymorphisms
Genome-wide association study
Population genetics
Genomics
NICKEL
ZINC
SEEDLINGS
11831 Plant biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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