Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence

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IMAGEN Consortium , Frere , P B , Vetter , N C , Artiges , E , Penttilä , J & Lemaitre , H 2020 , ' Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence ' , NeuroImage , vol. 210 , 116441 . https://doi.org/10.1016/j.neuroimage.2019.116441

Title: Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence
Author: IMAGEN Consortium; Frere, Pauline Bezivin; Vetter, Nora C.; Artiges, Eric; Penttilä, Jani; Lemaitre, Herve
Contributor organization: HYKS erva
Päijät-Häme Welfare Consortium
Date: 2020-04-15
Language: eng
Number of pages: 10
Belongs to series: NeuroImage
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2019.116441
URI: http://hdl.handle.net/10138/325270
Abstract: Though adolescence is a time of emerging sex differences in emotions, sex-related differences in the anatomy of the maturing brain has been under-explored over this period. The aim of this study was to investigate whether puberty and sexual differentiation in brain maturation could explain emotional differences between girls and boys during adolescence. We adapted a dedicated longitudinal pipeline to process structural and diffusion images from 335 typically developing adolescents between 14 and 16 years. We used voxel-based and Regions of Interest approaches to explore sex and puberty effects on brain and behavioral changes during adolescence. Sexual differences in brain maturation were characterized by amygdala and hippocampal volume increase in boys and decrease in girls. These changes were mediating the sexual differences in positive emotional regulation as illustrated by positive attributes increase in boys and decrease in girls. Moreover, the differential maturation rates between the limbic system and the prefrontal cortex highlighted the delayed maturation in boys compared to girls. This is the first study to show the sex effects on the differential cortico/subcortical maturation rates and the interaction between sex and puberty in the limbic system maturation related to positive attributes, reported as being protective from emotional disorders.
Subject: Diffusion tensor imaging
T1-weigthed imaging
Longitudinal
Adolescence
Sex difference
Puberty
WHITE-MATTER DEVELOPMENT
DEVELOPMENTAL TRAJECTORIES
BRAIN-DEVELOPMENT
PUBERTAL CHANGES
INTERNALIZING SYMPTOMS
CHILDHOOD
DEPRESSION
DIMORPHISM
AGE
STRENGTHS
3112 Neurosciences
3124 Neurology and psychiatry
515 Psychology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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