Nucleoskeletal regulation of transcription : Actin on MRTF

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http://hdl.handle.net/10138/325430

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Sidorenko , E & Vartiainen , M K 2019 , ' Nucleoskeletal regulation of transcription : Actin on MRTF ' , Experimental Biology and Medicine (Maywood) , vol. 244 , no. 15 , pp. 1372-1381 . https://doi.org/10.1177/1535370219854669

Title: Nucleoskeletal regulation of transcription : Actin on MRTF
Author: Sidorenko, Ekaterina; Vartiainen, Maria K.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
Date: 2019-11
Language: eng
Number of pages: 10
Belongs to series: Experimental Biology and Medicine (Maywood)
ISSN: 1535-3702
URI: http://hdl.handle.net/10138/325430
Abstract: Myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF) form an essential transcriptional complex that regulates the expression of many cytoskeletal genes in response to dynamic changes in the actin cytoskeleton. The nucleoskeleton, a "dynamic network of networks," consists of numerous proteins that contribute to nuclear shape and to its various functions, including gene expression. In this review, we will discuss recent work that has identified many nucleoskeletal proteins, such as nuclear lamina and lamina-associated proteins, nuclear actin, and the linker of the cytoskeleton and nucleoskeleton complex as important regulators of MRTF-A/SRF transcriptional activity, especially in the context of mechanical control of transcription. Impact statement Regulation of gene expression is a fundamental cellular process that ensures the appropriate response of a cell to its surroundings. Alongside biochemical signals, mechanical cues, such as substrate rigidity, have been recognized as key regulators of gene expression. Nucleoskeletal components play an important role in mechanoresponsive transcription, particularly in controlling the activity of MRTF-A/SRF transcription factors. This ensures that the cell can balance the internal and external mechanical forces by fine-tuning the expression of cytoskeletal genes.
Subject: Actin
nucleoskeleton
myocardin-related transcription factor
serum response factor nuclear lamina
transcription
SERUM RESPONSE FACTOR
NUCLEAR ACTIN
LAMIN-A/C
POLYPEPTIDE (LAP)2-ALPHA
STRUCTURAL ORGANIZATION
HNRNP-U
MYOCARDIN
COMPLEX
PROTEINS
ENVELOPE
3111 Biomedicine
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