Sidorenko , E & Vartiainen , M K 2019 , ' Nucleoskeletal regulation of transcription : Actin on MRTF ' , Experimental Biology and Medicine (Maywood) , vol. 244 , no. 15 , pp. 1372-1381 . https://doi.org/10.1177/1535370219854669
Title: | Nucleoskeletal regulation of transcription : Actin on MRTF |
Author: | Sidorenko, Ekaterina; Vartiainen, Maria K. |
Contributor organization: | Institute of Biotechnology Nuclear organization by actin |
Date: | 2019-11 |
Language: | eng |
Number of pages: | 10 |
Belongs to series: | Experimental Biology and Medicine (Maywood) |
ISSN: | 1535-3702 |
DOI: | https://doi.org/10.1177/1535370219854669 |
URI: | http://hdl.handle.net/10138/325430 |
Abstract: | Myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF) form an essential transcriptional complex that regulates the expression of many cytoskeletal genes in response to dynamic changes in the actin cytoskeleton. The nucleoskeleton, a "dynamic network of networks," consists of numerous proteins that contribute to nuclear shape and to its various functions, including gene expression. In this review, we will discuss recent work that has identified many nucleoskeletal proteins, such as nuclear lamina and lamina-associated proteins, nuclear actin, and the linker of the cytoskeleton and nucleoskeleton complex as important regulators of MRTF-A/SRF transcriptional activity, especially in the context of mechanical control of transcription. Impact statement Regulation of gene expression is a fundamental cellular process that ensures the appropriate response of a cell to its surroundings. Alongside biochemical signals, mechanical cues, such as substrate rigidity, have been recognized as key regulators of gene expression. Nucleoskeletal components play an important role in mechanoresponsive transcription, particularly in controlling the activity of MRTF-A/SRF transcription factors. This ensures that the cell can balance the internal and external mechanical forces by fine-tuning the expression of cytoskeletal genes. |
Subject: |
Actin
nucleoskeleton myocardin-related transcription factor serum response factor nuclear lamina transcription SERUM RESPONSE FACTOR NUCLEAR ACTIN LAMIN-A/C POLYPEPTIDE (LAP)2-ALPHA STRUCTURAL ORGANIZATION HNRNP-U MYOCARDIN COMPLEX PROTEINS ENVELOPE 3111 Biomedicine |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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