Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Show simple item record

dc.contributor.author Steinthorsdottir, Valgerdur
dc.contributor.author McGinnis, Ralph
dc.contributor.author Williams, Nicholas O.
dc.contributor.author Stefansdottir, Lilja
dc.contributor.author Thorleifsson, Gudmar
dc.contributor.author Shooter, Scott
dc.contributor.author Fadista, Joao
dc.contributor.author Sigurdsson, Jon K.
dc.contributor.author Auro, Kirsi M.
dc.contributor.author Berezina, Galina
dc.contributor.author Borges, Maria-Carolina
dc.contributor.author Bumpstead, Suzannah
dc.contributor.author Bybjerg-Grauholm, Jonas
dc.contributor.author Colgiu, Irina
dc.contributor.author Dolby, Vivien A.
dc.contributor.author Dudbridge, Frank
dc.contributor.author Engel, Stephanie M.
dc.contributor.author Franklin, Christopher S.
dc.contributor.author Frigge, Michael L.
dc.contributor.author Frisbaek, Yr
dc.contributor.author Geirsson, Reynir T.
dc.contributor.author Geller, Frank
dc.contributor.author Gretasdottir, Solveig
dc.contributor.author Gudbjartsson, Daniel F.
dc.contributor.author Harmon, Quaker
dc.contributor.author Hougaard, David Michael
dc.contributor.author Hegay, Tatyana
dc.contributor.author Helgadottir, Anna
dc.contributor.author Hjartardottir, Sigrun
dc.contributor.author Jääskeläinen, Tiina
dc.contributor.author Johannsdottir, Hrefna
dc.contributor.author Jonsdottir, Ingileif
dc.contributor.author Juliusdottir, Thorhildur
dc.contributor.author Kalsheker, Noor
dc.contributor.author Kasimov, Abdumadjit
dc.contributor.author Kemp, John P.
dc.contributor.author Kivinen, Katja
dc.contributor.author Klungsøyr, Kari
dc.contributor.author Lee, Wai K.
dc.contributor.author Melbye, Mads
dc.contributor.author Miedzybrodska , Zosia
dc.contributor.author Moffett, Ashley
dc.contributor.author Najmutdinova, Dilbar
dc.contributor.author Nishanova, Firuza
dc.contributor.author Olafsdottir, Thorunn
dc.contributor.author Perola, Markus
dc.contributor.author FINNPEC Consortium
dc.contributor.author Laivuori, Hannele
dc.contributor.author Heinonen, Seppo
dc.contributor.author Kajantie, Eero
dc.contributor.author Kere, Juha
dc.contributor.author Kivinen, Katja
dc.contributor.author Pouta, Anneli
dc.date.accessioned 2021-01-29T15:05:01Z
dc.date.available 2021-01-29T15:05:01Z
dc.date.issued 2020-12-25
dc.identifier.citation Steinthorsdottir , V , McGinnis , R , Williams , N O , Stefansdottir , L , Thorleifsson , G , Shooter , S , Fadista , J , Sigurdsson , J K , Auro , K M , Berezina , G , Borges , M-C , Bumpstead , S , Bybjerg-Grauholm , J , Colgiu , I , Dolby , V A , Dudbridge , F , Engel , S M , Franklin , C S , Frigge , M L , Frisbaek , Y , Geirsson , R T , Geller , F , Gretasdottir , S , Gudbjartsson , D F , Harmon , Q , Hougaard , D M , Hegay , T , Helgadottir , A , Hjartardottir , S , Jääskeläinen , T , Johannsdottir , H , Jonsdottir , I , Juliusdottir , T , Kalsheker , N , Kasimov , A , Kemp , J P , Kivinen , K , Klungsøyr , K , Lee , W K , Melbye , M , Miedzybrodska , Z , Moffett , A , Najmutdinova , D , Nishanova , F , Olafsdottir , T , Perola , M , FINNPEC Consortium , Laivuori , H , Heinonen , S , Kajantie , E , Kere , J , Kivinen , K & Pouta , A 2020 , ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ' , Nature Communications , vol. 11 , no. 1 , 5976 . https://doi.org/10.1038/s41467-020-19733-6
dc.identifier.other PURE: 156580855
dc.identifier.other PURE UUID: 1b0f47bd-1cc2-4a30-a132-30290eba4000
dc.identifier.other WOS: 000595964100004
dc.identifier.other ORCID: /0000-0002-1202-0936/work/87788209
dc.identifier.uri http://hdl.handle.net/10138/325500
dc.description.abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia. Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BODY-MASS INDEX
dc.subject CARDIOVASCULAR-DISEASE
dc.subject COHORT PROFILE
dc.subject FETAL
dc.subject GENOME-WIDE ASSOCIATION
dc.subject MEDICAL BIRTH REGISTRY
dc.subject METAANALYSIS
dc.subject PREGNANCY
dc.subject RISK
dc.subject VARIANTS
dc.subject 3123 Gynaecology and paediatrics
dc.title Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women en
dc.type Article
dc.contributor.organization Pregnancy and Genes
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Research Programs Unit
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Children's Hospital
dc.contributor.organization STEMM - Stem Cells and Metabolism Research Program
dc.contributor.organization Juha Kere / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41467-020-19733-6
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_020_19733_6.pdf 1.619Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record