Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Show simple item record Steinthorsdottir, Valgerdur McGinnis, Ralph Williams, Nicholas O. Stefansdottir, Lilja Thorleifsson, Gudmar Shooter, Scott Fadista, Joao Sigurdsson, Jon K. Auro, Kirsi M. Berezina, Galina Borges, Maria-Carolina Bumpstead, Suzannah Bybjerg-Grauholm, Jonas Colgiu, Irina Dolby, Vivien A. Dudbridge, Frank Engel, Stephanie M. Franklin, Christopher S. Frigge, Michael L. Frisbaek, Yr Geirsson, Reynir T. Geller, Frank Gretasdottir, Solveig Gudbjartsson, Daniel F. Harmon, Quaker Hougaard, David Michael Hegay, Tatyana Helgadottir, Anna Hjartardottir, Sigrun Jääskeläinen, Tiina Johannsdottir, Hrefna Jonsdottir, Ingileif Juliusdottir, Thorhildur Kalsheker, Noor Kasimov, Abdumadjit Kemp, John P. Kivinen, Katja Klungsøyr, Kari Lee, Wai K. Melbye, Mads Miedzybrodska , Zosia Moffett, Ashley Najmutdinova, Dilbar Nishanova, Firuza Olafsdottir, Thorunn Perola, Markus FINNPEC Consortium Laivuori, Hannele Heinonen, Seppo Kajantie, Eero Kere, Juha Kivinen, Katja Pouta, Anneli 2021-01-29T15:05:01Z 2021-01-29T15:05:01Z 2020-12-25
dc.identifier.citation Steinthorsdottir , V , McGinnis , R , Williams , N O , Stefansdottir , L , Thorleifsson , G , Shooter , S , Fadista , J , Sigurdsson , J K , Auro , K M , Berezina , G , Borges , M-C , Bumpstead , S , Bybjerg-Grauholm , J , Colgiu , I , Dolby , V A , Dudbridge , F , Engel , S M , Franklin , C S , Frigge , M L , Frisbaek , Y , Geirsson , R T , Geller , F , Gretasdottir , S , Gudbjartsson , D F , Harmon , Q , Hougaard , D M , Hegay , T , Helgadottir , A , Hjartardottir , S , Jääskeläinen , T , Johannsdottir , H , Jonsdottir , I , Juliusdottir , T , Kalsheker , N , Kasimov , A , Kemp , J P , Kivinen , K , Klungsøyr , K , Lee , W K , Melbye , M , Miedzybrodska , Z , Moffett , A , Najmutdinova , D , Nishanova , F , Olafsdottir , T , Perola , M , FINNPEC Consortium , Laivuori , H , Heinonen , S , Kajantie , E , Kere , J , Kivinen , K & Pouta , A 2020 , ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ' , Nature Communications , vol. 11 , no. 1 , 5976 .
dc.identifier.other PURE: 156580855
dc.identifier.other PURE UUID: 1b0f47bd-1cc2-4a30-a132-30290eba4000
dc.identifier.other WOS: 000595964100004
dc.identifier.other ORCID: /0000-0002-1202-0936/work/87788209
dc.description.abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia. Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BODY-MASS INDEX
dc.subject FETAL
dc.subject PREGNANCY
dc.subject RISK
dc.subject VARIANTS
dc.subject 3123 Gynaecology and paediatrics
dc.title Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women en
dc.type Article
dc.contributor.organization Pregnancy and Genes
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Research Programs Unit
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Children's Hospital
dc.contributor.organization STEMM - Stem Cells and Metabolism Research Program
dc.contributor.organization Juha Kere / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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