Farm-like indoor microbiota in non-farm homes protects children from asthma development

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Kirjavainen , P V , Karvonen , A M , Adams , R I , Täubel , M , Roponen , M , Tuoresmäki , P , Loss , G , Jayaprakash , B , Depner , M , Ege , M J , Renz , H , Pfefferle , P I , Schaub , B , Lauener , R , Hyvärinen , A , Knight , R , Heederik , D J J , von Mutius , E & Pekkanen , J 2019 , ' Farm-like indoor microbiota in non-farm homes protects children from asthma development ' , Nature Medicine , vol. 25 , no. 7 , pp. 1089-+ .

Title: Farm-like indoor microbiota in non-farm homes protects children from asthma development
Author: Kirjavainen, Pirkka V.; Karvonen, Anne M.; Adams, Rachel I.; Täubel, Martin; Roponen, Marjut; Tuoresmäki, Pauli; Loss, Georg; Jayaprakash, Balamuralikrishna; Depner, Martin; Ege, Markus Johannes; Renz, Harald; Pfefferle, Petra Ina; Schaub, Bianca; Lauener, Roger; Hyvärinen, Anne; Knight, Rob; Heederik, Dick J. J.; von Mutius, Erika; Pekkanen, Juha
Contributor organization: Department of Public Health
University of Helsinki
Date: 2019-07
Language: eng
Number of pages: 17
Belongs to series: Nature Medicine
ISSN: 1078-8956
Abstract: Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today(1). The asthma-protective effect of farms appears to be associated with rich home dust microbiota(2,3), which could be used to model a health-promoting indoor microbiome. Here we show by modeling differences in house dust microbiota composition between farm and non-farm homes of Finnish birth cohorts(4) that in children who grow up in non-farm homes, asthma risk decreases as the similarity of their home bacterial microbiota composition to that of farm homes increases. The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-associated bacterial taxa. The protective effect was independent of richness and total bacterial load and was associated with reduced proinflammatory cytokine responses against bacterial cell wall components ex vivo. We were able to reproduce these findings in a study among rural German children(2) and showed that children living in German non-farm homes with an indoor microbiota more similar to Finnish farm homes have decreased asthma risk. The indoor dust microbiota composition appears to be a definable, reproducible predictor of asthma risk and a potential modifiable target for asthma prevention.
1182 Biochemistry, cell and molecular biology
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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