Tips and turns of bacteriophytochrome photoactivation

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Takala , H , Edlund , P , Ihalainen , J A & Westenhoff , S 2020 , ' Tips and turns of bacteriophytochrome photoactivation ' , Photochemical & Photobiological Sciences , vol. 19 , no. 11 , pp. 1488-1510 . https://doi.org/10.1039/d0pp00117a

Title: Tips and turns of bacteriophytochrome photoactivation
Author: Takala, Heikki; Edlund, Petra; Ihalainen, Janne A.; Westenhoff, Sebastian
Contributor: University of Helsinki, Medicum
Date: 2020-11-01
Language: eng
Number of pages: 23
Belongs to series: Photochemical & Photobiological Sciences
ISSN: 1474-905X
URI: http://hdl.handle.net/10138/325620
Abstract: Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction and movement in plants, fungi and bacteria. Phytochromes switch between two photophysical states depending on the light conditions. In analogy to molecular machines, light absorption induces a series of structural changes that are transduced from the bilin chromophore, through the protein, and to the output domains. Recent progress towards understanding this structural mechanism of signal transduction has been manifold. We describe this progress with a focus on bacteriophytochromes. We describe the mechanism along three structural tiers, which are the chromophore-binding pocket, the photosensory module, and the output domains. We discuss possible interconnections between the tiers and conclude by presenting future directions and open questions. We hope that this review may serve as a compendium to guide future structural and spectroscopic studies designed to understand structural signaling in phytochromes.
Subject: INFRARED FLUORESCENT PROTEINS
CHROMOPHORE-BINDING DOMAIN
INDUCED CONFORMATIONAL-CHANGES
INDUCED PROTON RELEASE
CRYSTAL-STRUCTURE
RESONANCE RAMAN
PHYTOCHROME-B
HISTIDINE KINASES
SIGNAL-TRANSDUCTION
AGROBACTERIUM-TUMEFACIENS
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
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