The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

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Vannini , N , Campos , V , Girotra , M , Trachsel , V , Rojas-Sutterlin , S , Tratwal , J , Ragusa , S , Stefanidis , E , Ryu , D , Rainer , P Y , Nikitin , G , Giger , S , Li , T Y , Semilietof , A , Oggier , A , Yersin , Y , Tauzin , L , Pirinen , E , Cheng , W-C , Ratajczak , J , Canto , C , Ehrbar , M , Sizzano , F , Petrova , T V , Vanhecke , D , Zhang , L , Romero , P , Nahimana , A , Cherix , S , Duchosal , M A , Ho , P-C , Deplancke , B , Coukos , G , Auwerx , J , Lutolf , M P & Naveiras , O 2019 , ' The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance ' , Cell Stem Cell , vol. 24 , no. 3 , pp. 405-+ . https://doi.org/10.1016/j.stem.2019.02.012

Title: The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Author: Vannini, Nicola; Campos, Vasco; Girotra, Mukul; Trachsel, Vincent; Rojas-Sutterlin, Shanti; Tratwal, Josefine; Ragusa, Simone; Stefanidis, Evangelos; Ryu, Dongryeol; Rainer, Pernille Y.; Nikitin, Gena; Giger, Sonja; Li, Terytty Y.; Semilietof, Aikaterini; Oggier, Aurelien; Yersin, Yannick; Tauzin, Loic; Pirinen, Eija; Cheng, Wan-Chen; Ratajczak, Joanna; Canto, Carles; Ehrbar, Martin; Sizzano, Federico; Petrova, Tatiana V.; Vanhecke, Dominique; Zhang, Lianjun; Romero, Pedro; Nahimana, Aimable; Cherix, Stephane; Duchosal, Michel A.; Ho, Ping-Chih; Deplancke, Bart; Coukos, George; Auwerx, Johan; Lutolf, Matthias P.; Naveiras, Olaia
Contributor: University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2019-03-07
Language: eng
Number of pages: 21
Belongs to series: Cell Stem Cell
ISSN: 1934-5909
URI: http://hdl.handle.net/10138/325758
Abstract: It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD(+)-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD(+)-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision, and unveiling the potential of NR to improve recovery of patients suffering from hematological failure including post chemo- and radiotherapy.
Subject: STEM-CELL TRANSPLANTATION
GREEN FLUORESCENT PROTEIN
SELF-RENEWAL
LIFE-SPAN
METABOLIC CHECKPOINT
PROGENITOR CELLS
MITOPHAGY
AUTOPHAGY
HOMEOSTASIS
LONGEVITY
1182 Biochemistry, cell and molecular biology
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